MAP2K2 and CCNDBP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MAP2K2	CCNDBP1
Description		mitogen-activated protein kinase kinase 2	cyclin D1 binding protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding PDZ Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Scaffold Protein Binding	Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Regulation Of Stress-activated MAPK Cascade Peptidyl-serine Autophosphorylation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Early Endosome To Late Endosome Transport	Cell Cycle Regulation Of Cell Cycle
Pathways		MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs		Bosutinib Trametinib
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Heel bone mineral density ( 30598549) Height ( 29782485) Pulse pressure ( 30224653)
Interacting Genes		18 interacting genes: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 GRIN1 GRIN2D LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 RAF1 RGS12 RIPOR2 ZNF207	81 interacting genes: AMPD2 ARHGAP22 ATP4B C22orf23 C6orf226 CCDC146 CCND1 CDK18 CDKN2A CFAP65 CNNM3 CUL5 DMRT3 DOCK2 FAM110A FAM126A FAM161A FAM74A4 FH GLIDR GRAP2 GSTK1 HSPB1 ILF2 IMP3 MAP2K2 MOS MRPL15 MRPS9 MTDH NAIF1 NANOS2 NEURL3 NUDCD3 PAXIP1 PIAS2 PIMREG PMP2 PRPF31 PSMB10 PTF1A RBP5 RPL28 RPL39L RPLP0 RPS28 SASH1 SIRT6 SPG7 STK25 SYF2 TEAD4 TFPT THAP10 THAP7 TMEM120B TRAPPC5 TTC23 TYMSOS ZBTB24 ZGPAT ZNF124 ZNF136 ZNF169 ZNF20 ZNF230 ZNF334 ZNF394 ZNF417 ZNF439 ZNF440 ZNF490 ZNF555 ZNF564 ZNF581 ZNF627 ZNF670 ZNF697 ZNF707 ZNRF2P1 ZSCAN26
Entrez ID		5605	23582
HPRD ID		03164	06156
Ensembl ID		ENSG00000126934	ENSG00000166946
Uniprot IDs		P36507	O95273
PDB IDs		1S9I 4H3Q	3AY5
Enriched GO Terms of Interacting Partners?
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