PCGF2 and HSF2

Number of citations of the paper that reports this interaction (PubMedID 18211895)
11

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid)

		PCGF2	HSF2
Description		polycomb group ring finger 2	heat shock transcription factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Promoter-specific Chromatin Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Silencing Anterior/posterior Pattern Specification Histone Acetylation Histone H2A-K119 Monoubiquitination Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of G0 To G1 Transition Negative Regulation Of Apoptotic Signaling Pathway	Transcription By RNA Polymerase II Spermatogenesis Cellular Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Heat Stress
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS			Atrial fibrillation ( 28416822 30061737 29892015) Disease progression in age-related macular degeneration ( 29346644) Lymphocyte counts ( 27863252) Optic cup area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Pulse pressure ( 30224653 27841878) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Word reading ( 30741946)
Interacting Genes		21 interacting genes: ABHD6 CBX2 CBX6 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PHC2 RBCK1 RNF2 SPDEF UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7	15 interacting genes: CDC20 CDC27 CUL3 HSF1 HSF2BP MTUS2 NCAPG NUP62 PCGF2 PPP2R1A SUMO2 SUMO3 TPM3 UBE2I WDR5
Entrez ID		7703	3298
HPRD ID		10621	00779
Ensembl ID		ENSG00000277258	ENSG00000025156
Uniprot IDs		A0A024R1V6 P35227	Q03933 Q9BS48
PDB IDs			5D8K 5D8L 5HDK
Enriched GO Terms of Interacting Partners?
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