PCGF2 and GJB5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PCGF2	GJB5
Description		polycomb group ring finger 2	gap junction protein beta 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Connexin Complex Integral Component Of Membrane
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Silencing Anterior/posterior Pattern Specification Histone Acetylation Histone H2A-K119 Monoubiquitination Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of G0 To G1 Transition Negative Regulation Of Apoptotic Signaling Pathway	Cell Communication Epidermis Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation Labyrinthine Layer Morphogenesis Epididymis Development
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6	Gap junction assembly
Drugs
Diseases
GWAS			Narcolepsy ( 23459209) Sleep duration (short sleep) ( 30846698) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		21 interacting genes: ABHD6 CBX2 CBX6 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PHC2 RBCK1 RNF2 SPDEF UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7	6 interacting genes: GSK3B LMNA MED1 MYL2 PCGF2 TRIM2
Entrez ID		7703	2709
HPRD ID		10621	06840
Ensembl ID		ENSG00000277258	ENSG00000189280
Uniprot IDs		A0A024R1V6 P35227	O95377
PDB IDs
Enriched GO Terms of Interacting Partners?
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