YES1 and GP6

Number of citations of the paper that reports this interaction (PubMedID 1715582)
97

Data Source:
HPRD (in vivo)

		YES1	GP6
Description		YES proto-oncogene 1, Src family tyrosine kinase	glycoprotein VI platelet
Image
GO Annotations	Cellular Component	Golgi Apparatus Microtubule Organizing Center Cytosol Actin Filament Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Exosome Tetraspanin-enriched Microdomain
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Ion Channel Binding	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Signaling Receptor Activity
	Biological Process	Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Glucose Transmembrane Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Regulation Of Vascular Permeability Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus	Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Platelet Activation Leukocyte Migration
Pathways		Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling CD28 co-stimulation CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis	GPVI-mediated activation cascade Cell surface interactions at the vascular wall Platelet Adhesion to exposed collagen
Drugs		Dasatinib
Diseases
GWAS		Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 30224653 29403010 30487518 30578418)	Blood protein levels ( 30072576 28240269) Breast cancer and/or colorectal cancer ( 29698419) Mean platelet volume ( 27863252) Platelet aggregation ( 20526338 29185836) Platelet distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Venous thromboembolism ( 31420334)
Interacting Genes		54 interacting genes: ADAM12 ADAM15 BECN1 C1orf94 CBL CD2AP CD36 CD46 CDH1 CDKN1B CSF1R DLG4 DOK1 DVL2 EPHB2 FASLG FGFR1 FLT1 FUNDC1 FXR2 GP6 ITGB4 JAK2 KDR KHDRBS1 KIT MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PTEN PTK2 PTPRE RASA1 RPL10 SKAP2 SLC9A3R1 SOCS3 SPRR2A SSBP3 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRPV4 TYRO3 ZBTB8A ZNF512B	7 interacting genes: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1
Entrez ID		7525	51206
HPRD ID		01285	10406
Ensembl ID		ENSG00000176105	ENSG00000088053
Uniprot IDs		P07947	Q9HCN6
PDB IDs		2HDA	2GI7 5OU7 5OU8 5OU9
Enriched GO Terms of Interacting Partners?
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