FMNL1 and PFN2

Number of citations of the paper that reports this interaction (PubMedID 10958683)
32

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FMNL1	PFN2
Description		formin like 1	profilin 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Cortex Membrane Bleb Phagocytic Vesicle Extracellular Exosome	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Molecular_function Protein Binding Profilin Binding GTPase Activating Protein Binding Rac GTPase Binding Actin Filament Binding	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity
	Biological Process	Substrate-dependent Cell Migration Regulation Of Cell Shape Cell Migration Cortical Actin Cytoskeleton Organization Actin Filament Severing	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis
Pathways		RHO GTPases Activate Formins RHO GTPases Activate Formins	Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs			1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane 1-(2-Methoxy-Ethoxy)-2-{2-[2-(2-Methoxy-Ethoxy]-Ethoxy}-Ethane
Diseases
GWAS		Asthma ( 31619474) Craniofacial microsomia ( 26853712) Hypothyroidism ( 30367059) Male-pattern baldness ( 28196072) Thyroid stimulating hormone levels ( 30367059)
Interacting Genes		10 interacting genes: APP GAS7 HMG20A PFN1 PFN2 PRPF40A RAC1 SRPK2 TCERG1 XRCC6	32 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		752	5217
HPRD ID		06876	01451
Ensembl ID		ENSG00000184922	ENSG00000070087
Uniprot IDs		O95466	P35080
PDB IDs		4YDH	1D1J
Enriched GO Terms of Interacting Partners?
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