PFN2 and WDR33

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	WDR33
Description		profilin 2	WD repeat domain 33
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Fibrillar Center Collagen Trimer Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity	RNA Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	MRNA Splicing, Via Spliceosome Postreplication Repair Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Export From Nucleus Spermatogenesis MRNA 3'-end Processing
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs		1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane 1-(2-Methoxy-Ethoxy)-2-{2-[2-(2-Methoxy-Ethoxy]-Ethoxy}-Ethane
Diseases
GWAS			Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778)
Interacting Genes		32 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	16 interacting genes: CDK4 EEF1G GIT1 KAT7 NEK9 PFN2 PRMT1 RBM48 SH3GL3 TGFBR1 TP53 UBC UTP14A WWOX ZBTB16 ZHX1
Entrez ID		5217	55339
HPRD ID		01451	11680
Ensembl ID		ENSG00000070087	ENSG00000136709
Uniprot IDs		P35080	Q9C0J8
PDB IDs		1D1J	6BLY 6BM0 6DNH 6F9N 6FBS 6FUW 6URG 6URO
Enriched GO Terms of Interacting Partners?
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