WIPF1 and WWP2

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		WIPF1	WWP2
Description		WAS/WASL interacting protein family member 1	WW domain containing E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Ruffle Cytosol Actin Filament Actin Cytoskeleton Actin Cortical Patch Cytoplasmic Vesicle	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Actin Filament Binding	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Actin Cortical Patch Assembly Endocytosis Actin Polymerization Or Depolymerization Regulation Of Cell Shape Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Actin Nucleation Actin Cortical Patch Localization Response To Other Organism Protein-containing Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of PTEN stability and activity NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Systolic blood pressure ( 27841878) Urate levels (BMI interaction) ( 25811787)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 28552196 31562340) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Plantar fascial disorders ( 29534260) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Triglycerides ( 30275531)
Interacting Genes		22 interacting genes: ABI2 ACTC1 ACTG1 ALAS1 APBB1 CDC42 CRKL CTTN FASTK GRB2 HCK HOMER3 ITSN2 NCK1 PRKCQ PRPF40A SEC24C WAS WASL WBP4 WWP2 ZAP70	60 interacting genes: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 GRAP2 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 NUTF2 PAIP1 PDLIM7 PSMF1 PTEN RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFTPC SMAD3 SMAD7 SNRPC SPART TFAP2A TNK2 TP53BP2 TP73 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1 ZNF688
Entrez ID		7456	11060
HPRD ID		03835	03812
Ensembl ID		ENSG00000115935	ENSG00000198373
Uniprot IDs		A0A140VJZ9 O43516 Q2YDC4	A0A024R711 B4DHF6 O00308
PDB IDs		2A41	4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS
Enriched GO Terms of Interacting Partners?
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