VRK2 and PLD3

		VRK2	PLD3
Description		VRK serine/threonine kinase 2	phospholipase D family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Protein-containing Complex	Golgi Membrane Lysosomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane Early Endosome Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Domain Specific Binding	Phospholipase D Activity Protein Binding Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity
	Biological Process	Protein Phosphorylation Viral Process Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	Immune System Process DNA Metabolic Process Inflammatory Response Myotube Differentiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways			Synthesis of PG Role of phospholipids in phagocytosis
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Autism spectrum disorder or schizophrenia ( 28540026) Depression ( 29700475) Epilepsy ( 25087078) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Hirschsprung disease ( 27702942) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 28991256 25056061 19571808 29483656 27922604 30285260) Sleep duration ( 27992416 27494321) Sleep duration (oversleepers vs undersleepers) ( 27494321)	Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)
Interacting Genes		11 interacting genes: CCT2 CCT4 CDC42 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 PLD3 RBX1 TCP1	11 interacting genes: ANXA7 ATG16L1 BCL2L1 CIC HGS NFKB1 SOX4 SPP1 STK11 TK1 VRK2
Entrez ID		7444	23646
HPRD ID		03702	07148
Ensembl ID		ENSG00000028116	ENSG00000105223
Uniprot IDs		A8K9L2 Q86Y07	A0A024R0Q4 Q8IV08
PDB IDs		2V62 5UU1 6NCG
Enriched GO Terms of Interacting Partners?
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