VRK2 and CCT4

Number of citations of the paper that reports this interaction (PubMedID 24298020)
12

Data Source:
BioGRID (pull down)

		VRK2	CCT4
Description		VRK serine/threonine kinase 2	chaperonin containing TCP1 subunit 4
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Protein-containing Complex	Zona Pellucida Receptor Complex Nucleoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Melanosome Cell Projection Cell Body Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Domain Specific Binding	RNA Binding Protein Binding ATP Binding Unfolded Protein Binding
	Biological Process	Protein Phosphorylation Viral Process Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways			Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Autism spectrum disorder or schizophrenia ( 28540026) Depression ( 29700475) Epilepsy ( 25087078) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Hirschsprung disease ( 27702942) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 28991256 25056061 19571808 29483656 27922604 30285260) Sleep duration ( 27992416 27494321) Sleep duration (oversleepers vs undersleepers) ( 27494321)	Erectile dysfunction ( 30583798) Plasma free amino acid levels ( 30659259)
Interacting Genes		11 interacting genes: CCT2 CCT4 CDC42 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 PLD3 RBX1 TCP1	10 interacting genes: ACTA1 ACTA2 ACTB CCNE1 CFAP52 COP1 MTDH PRPF40A RPS6KA1 VRK2
Entrez ID		7444	10575
HPRD ID		03702	05506
Ensembl ID		ENSG00000028116	ENSG00000115484
Uniprot IDs		A8K9L2 Q86Y07	P50991
PDB IDs		2V62 5UU1 6NCG	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8
Enriched GO Terms of Interacting Partners?
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