RELN and PCDHA4

Number of citations of the paper that reports this interaction (PubMedID 10612399)
37

Data Source:
HPRD (in vitro, in vivo)

		RELN	PCDHA4
Description		reelin	protocadherin alpha 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Dendrite Extracellular Matrix Neuron Projection	Integral Component Of Plasma Membrane
	Molecular Function	Serine-type Peptidase Activity Metal Ion Binding Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	Calcium Ion Binding Protein Binding Identical Protein Binding
	Biological Process	Cell Morphogenesis Involved In Differentiation Neuron Migration Proteolysis Cell Adhesion Axon Guidance Central Nervous System Development Brain Development Long-term Memory Associative Learning Glial Cell Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Dendrite Development Peptidyl-tyrosine Phosphorylation Spinal Cord Patterning Ventral Spinal Cord Development Hippocampus Development Cerebral Cortex Tangential Migration Layer Formation In Cerebral Cortex Positive Regulation Of TOR Signaling Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Response To Pain Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Modulation Of Chemical Synaptic Transmission Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Synapse Maturation NMDA Glutamate Receptor Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Lateral Motor Column Neuron Migration Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Lateral Motor Column Neuron Migration Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development
Pathways		Reelin signalling pathway
Drugs
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Alzheimer's disease ( 20452100) Bitter alcoholic beverage consumption ( 31046077) Intraocular pressure ( 29785010) Metabolite levels (Pyroglutamine) ( 23934736) Morning person ( 30696823) Multiple sclerosis (age of onset) ( 19010793) Night sleep phenotypes ( 27126917) Otosclerosis ( 19230858) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Schizophrenia ( 18282107) SjÃ¶gren's syndrome ( 28076899) Sucrose liking ( 31005972) Type 2 diabetes ( 30054458 30297969) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Neutrophil count ( 27863252) Schizophrenia ( 28991256 29483656) Sum basophil neutrophil counts ( 27863252)
Interacting Genes		6 interacting genes: DAB1 LRP8 PCDHA4 PCDHA6 SQSTM1 VLDLR	15 interacting genes: APLP1 CCDC90B EEF1A1 ERG28 GAPDH GDF9 IGSF21 LRIF1 RBM48 RELN SETDB1 SGTA TLE1 TP53 UNC119
Entrez ID		5649	56144
HPRD ID		02742	07322
Ensembl ID		ENSG00000189056	ENSG00000204967
Uniprot IDs		P78509	Q59H34 Q9UN74
PDB IDs
Enriched GO Terms of Interacting Partners?
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