EZR and ICAM3

Number of citations of the paper that reports this interaction (PubMedID 9705328)
83

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		EZR	ICAM3
Description		ezrin	intercellular adhesion molecule 3
Image
GO Annotations	Cellular Component	Fibrillar Center Ruffle Immunological Synapse Uropod Extracellular Space Cell Cytoplasm Endosome Cytosol Actin Filament Plasma Membrane Microvillus Brush Border Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Protein-containing Complex Ciliary Basal Body Cell Projection Cell Body Microspike Plasma Membrane Raft Apical Part Of Cell Perinuclear Region Of Cytoplasm Cell Tip Extracellular Exosome Invadopodium Cell Periphery Astrocyte Projection Schwann Cell Microvillus Cytoplasmic Side Of Apical Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Binding Actin Binding Protein Binding Microtubule Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding S100 Protein Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding Protein Kinase A Binding ATPase Binding Disordered Domain Specific Binding	Signaling Receptor Binding Integrin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intestinal D-glucose Absorption Sphingosine-1-phosphate Receptor Signaling Pathway Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Protein Kinase A Signaling Gland Morphogenesis Membrane To Membrane Docking Microvillus Assembly Astral Microtubule Organization Actin Cytoskeleton Reorganization Receptor Internalization Regulation Of Microvillus Length Regulation Of Actin Cytoskeleton Organization Cellular Protein-containing Complex Localization Positive Regulation Of Multicellular Organism Growth Cortical Microtubule Organization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Secretion Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Establishment Of Centrosome Localization Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Protein Localization To Cell Cortex Negative Regulation Of Interleukin-2 Secretion Regulation Of NIK/NF-kappaB Signaling Regulation Of Organelle Assembly Terminal Web Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of P38MAPK Cascade Positive Regulation Of Early Endosome To Late Endosome Transport	Stimulatory C-type Lectin Receptor Signaling Pathway Phagocytosis Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion
Pathways		Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling
Drugs
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Hair color ( 29662168)	Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		51 interacting genes: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MME MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 VPS11 WFDC1 WWOX	11 interacting genes: APP CD209 CLEC4M EZR GCC2 ITGAD ITGAL ITGB2 MSN PRKCQ ZBTB16
Entrez ID		7430	3385
HPRD ID		00475	00889
Ensembl ID		ENSG00000092820	ENSG00000076662
Uniprot IDs		P15311	A0A024R7C1 K7ERN2 P32942
PDB IDs		1NI2 4RM8 4RM9 4RMA	1T0P
Enriched GO Terms of Interacting Partners?
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