VDR and RXRB

Number of citations of the paper that reports this interaction (PubMedID 15604093)
54

Data Source:
HPRD (two hybrid)

		VDR	RXRB
Description		vitamin D receptor	retinoid X receptor beta
Image
GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Vitamin D Binding Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Lithocholic Acid Receptor Activity Retinoid X Receptor Binding Vitamin D Response Element Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding Calcitriol Binding Lithocholic Acid Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Retinoic Acid-responsive Element Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Skeletal System Development Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Calcium Ion Transport Cellular Calcium Ion Homeostasis Signal Transduction Multicellular Organism Development Lactation Negative Regulation Of Cell Proliferation Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Vitamin D 24-hydroxylase Activity Cell Differentiation Response To Lipid Bile Acid Signaling Pathway Vitamin D Metabolic Process Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Decidualization Intestinal Absorption Lipid Homeostasis Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of Calcidiol 1-monooxygenase Activity Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Cellular Response To Lipopolysaccharide	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Response To Retinoic Acid Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development
Pathways		Vitamin D (calciferol) metabolism Nuclear Receptor transcription pathway SUMOylation of intracellular receptors	PPARA activates gene expression Nuclear Receptor transcription pathway Signaling by Retinoic Acid NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs		Calcitriol Calcidiol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol 1-alpha, 25-dihydroxyl-20-epi-22-oxa-24, 26 ,27-trihomovitamin D3 Seocalcitol Cholesterol Inecalcitol Becocalcidiol CTA018 Eldecalcitol Doxercalciferol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Vitamin D Curcumin	Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Bezafibrate 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid Phthalic Acid Doconexent N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diseases		Tuberculosis Localized autosomal recessive hypotrichosis
GWAS		Asthma (adult onset) ( 31036433) Gout ( 22179738) Gut microbiota (beta diversity) ( 27723756) Inflammatory bowel disease ( 23128233) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Menarche (age at onset) ( 25231870)	Wegener's granulomatosis ( 23740775)
Interacting Genes		74 interacting genes: ACTN4 ACVR1 BAG1 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GOLM2 GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED12 MED14 MED23 MEOX2 MMRN2 MYC NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 POLR2A POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PSMC5 RB1 RNF14 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TDG TRIM24 TRIP13 ZBTB16	45 interacting genes: AKAP13 CACNA1B CALCOCO2 CCDC57 EXOSC8 GOLGA2 GTF2H1 KRT40 MAP4 MID2 NCOA1 NCOA3 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR2C2 NR2E3 NR3C1 NR4A2 NRIP1 PLSCR1 PPARD PPARG PSTPIP1 PTMS RARA RARB RARG SIAH1 SPOP TACC2 TADA3 TAF11 TFCP2 TFIP11 THRA THRB TP53BP2 TRIM27 TRIM37 UBL7 VDR ZDHHC12
Entrez ID		7421	6257
HPRD ID		03463	01578
Ensembl ID		ENSG00000111424	ENSG00000204231
Uniprot IDs		F1D8P8 P11473	A0A0G2JKR7 A0A0S2Z570 B7Z7J5 P28702 Q5STP9
PDB IDs		1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 3W0A 3W0C 3W0Y 3WGP 3WWR 3X31 3X36 4G2I 4ITE 4ITF 5GT4 5V39 5YSY 5YT2	1H9U 1UHL 5HJP 5I4V 5KYA 5KYJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?