UBE2B and RAD18

Number of citations of the paper that reports this interaction (PubMedID 18316726)
85

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		UBE2B	RAD18
Description		ubiquitin conjugating enzyme E2 B	RAD18 E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Chromatin Nuclear Chromatin XY Body Cell Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane HULC Complex	Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Y-form DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Single-stranded DNA-dependent ATP-dependent DNA Helicase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Maintenance Of Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Histone Ubiquitination Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Response To Drug DNA Damage Response, Detection Of DNA Damage Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Protein Autoubiquitination Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway	DNA Repair Postreplication Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Protein Ubiquitination DNA Damage Response, Detection Of DNA Damage Protein Autoubiquitination Positive Regulation Of Chromosome Segregation Negative Regulation Of Cell Death
Pathways		Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Relative amplitude of rest-activity cycles ( 30120083)	Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798)
Interacting Genes		25 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 FBN2 H2AC20 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBR1 UBR2 UBR3 UBR5 UNC119	25 interacting genes: DZIP3 MAGEA4 MAP3K1 MAPK8 MLKL NBN PCGF6 PCNA POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7
Entrez ID		7320	56852
HPRD ID		01533	09242
Ensembl ID		ENSG00000119048	ENSG00000070950
Uniprot IDs		P63146	Q9NS91
PDB IDs		1JAS 1NXA 2Y4W 2YB6 2YBF	2MRE 2MRF 2Y43 2YBF 5VF0
Enriched GO Terms of Interacting Partners?
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