TTN and NBR1

Number of citations of the paper that reports this interaction (PubMedID 15802564)
180

Data Source:
HPRD (in vitro, two hybrid)

		TTN	NBR1
Description		titin	NBR1 autophagy cargo receptor
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Extracellular Region Cytosol Striated Muscle Thin Filament Sarcomere Z Disc M Band I Band Extracellular Exosome	Phagophore Assembly Site Nucleoplasm Mitochondrion Lysosome Late Endosome Autophagosome Cytosol Membrane Nuclear Body M Band Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity	Protein Binding Zinc Ion Binding Ubiquitin Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Platelet Degranulation Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Actin Filament Organization Mitotic Chromosome Condensation Positive Regulation Of Gene Expression Protein Kinase A Signaling Peptidyl-tyrosine Phosphorylation Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Cardiac Muscle Fiber Development Sarcomerogenesis Positive Regulation Of Protein Secretion Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Striated Muscle Myosin Thick Filament Assembly	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation
Pathways		Platelet degranulation Striated Muscle Contraction	Pexophagy Pexophagy
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS		Atrial fibrillation ( 29290336 30061737 29892015) Bone mineral density (hip) ( 30172743) Breast size ( 22747683) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) PR interval ( 30046033) QT interval ( 20031603 29213071 24952745) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Resting heart rate ( 27798624) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		31 interacting genes: ACTA1 ACTN1 ACTN2 ANK1 ANKRD1 ANKRD2 ANKRD23 CALM1 CAPN3 CRYAB FHL1 FHL2 FLNA HSPB2 MAPK1 MYBPC1 MYBPC3 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB OBSCN SQSTM1 SRPK2 TCAP TRIM55 TRIM63 TSC22D2 VAV2	21 interacting genes: ATXN1L AXIN1 CALM1 CIB1 FEZ1 GABARAP GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A MAP1LC3B MAP2K4 SQSTM1 SYT4 TTN UBC UBE2D2 UBE2D3 USP8 VTA1
Entrez ID		7273	4077
HPRD ID		01787	01326
Ensembl ID		ENSG00000155657	ENSG00000188554
Uniprot IDs		A0A0A0MRA3 A0A0A0MTS7 Q7Z3B7 Q8WZ42	A0A024R1V3 B7Z5R6 Q14596
PDB IDs		1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3 4C4K 4JNW 4O00 4QEG 4UOW 5BS0 5JDD 5JDE 5JDJ 5JOE 6DL4 6H4L 6HCI 6I0Y 6SDB	1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE
Enriched GO Terms of Interacting Partners?
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