TRPC4 and TRPC5

Number of citations of the paper that reports this interaction (PubMedID 12032305)
213

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)
HPRD (in vivo, in vitro)

		TRPC4	TRPC5
Description		transient receptor potential cation channel subfamily C member 4	transient receptor potential cation channel subfamily C member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell-cell Junction Cell Surface Basolateral Plasma Membrane Cortical Cytoskeleton Cation Channel Complex Calcium Channel Complex	Cell Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Dendrite Growth Cone Cation Channel Complex Calcium Channel Complex Neuronal Cell Body Membrane Raft
	Molecular Function	Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding	Actin Binding Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Calcium Ion Transport Manganese Ion Transport Gamma-aminobutyric Acid Secretion Oligodendrocyte Differentiation Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Import Calcium Ion Transmembrane Transport	Calcium Ion Transport Manganese Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Positive Regulation Of Cell Proliferation Positive Regulation Of Peptidyl-threonine Phosphorylation Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Regulation Of Membrane Hyperpolarization
Pathways		TRP channels Role of second messengers in netrin-1 signaling	TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Mild influenza (H1N1) infection ( 26379185) Obesity-related traits ( 23251661) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Smoking behavior ( 19247474)
Interacting Genes		10 interacting genes: DRD2 ITCH ITPR1 ITPR2 ITPR3 MX1 SLC9A3R1 TJP1 TRPC1 TRPC5	9 interacting genes: DRD2 ENKUR ITPR3 MX1 SLC9A3R1 STMN2 STMN3 TRPC1 TRPC4
Entrez ID		7223	7224
HPRD ID		09154	02273
Ensembl ID		ENSG00000133107	ENSG00000072315
Uniprot IDs		Q9UBN4	Q9UL62
PDB IDs
Enriched GO Terms of Interacting Partners?
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