HSP90B1 and MTTP

Number of citations of the paper that reports this interaction (PubMedID 9694898)
21

Data Source:
HPRD (in vivo)

		HSP90B1	MTTP
Description		heat shock protein 90 beta family member 1	microsomal triglyceride transfer protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Basolateral Plasma Membrane Receptor Complex
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding	Lipid Transporter Activity Protein Binding Phospholipid Transporter Activity Lipid Binding Protein Heterodimerization Activity Intermembrane Phospholipid Transfer Activity Ceramide 1-phosphate Transporter Activity
	Biological Process	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Protein Transport Cytokine-mediated Signaling Pathway Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Sequestering Of Calcium Ion Cellular Response To ATP	Lipid Metabolic Process Protein Secretion Phospholipid Transport Triglyceride Transport Plasma Lipoprotein Particle Assembly Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Cholesterol Homeostasis Ceramide 1-phosphate Transport
Pathways		Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation	VLDL assembly Chylomicron assembly
Drugs		Rifabutin 2-Chlorodideoxyadenosine Geldanamycin 1-Methoxy-2-(2-Methoxyethoxy)Ethane N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper	Hesperetin Implitapide Lomitapide
Diseases			Abetalipoproteinemia; Bassen-Kornzweig Disease
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)	Celiac disease ( 23936387) HDL cholesterol ( 30275531) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		28 interacting genes: APOB ASGR1 BIRC2 CACYBP CCT2 CSNK2A1 CSNK2A2 EGFR ERBB2 ESR1 FANCC HSPA9 LRP1 MAPK6 MDM2 MTTP NKX3-1 OS9 POLR2E PTPN11 SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11	2 interacting genes: APOB HSP90B1
Entrez ID		7184	4547
HPRD ID		01860	01144
Ensembl ID		ENSG00000166598	ENSG00000138823
Uniprot IDs		P14625 V9HWP2	B7Z7X3 E9PBP6 P55157
PDB IDs		4NH9
Enriched GO Terms of Interacting Partners?
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