MTTP and HSP90B1

Number of citations of the paper that reports this interaction (PubMedID 9694898)
21

Data Source:
HPRD (in vivo)

		MTTP	HSP90B1
Description		microsomal triglyceride transfer protein	heat shock protein 90 beta family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Basolateral Plasma Membrane Receptor Complex	Extracellular Region Cell Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Lipid Transporter Activity Protein Binding Phospholipid Transporter Activity Lipid Binding Protein Heterodimerization Activity Intermembrane Phospholipid Transfer Activity Ceramide 1-phosphate Transporter Activity	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	Lipid Metabolic Process Protein Secretion Phospholipid Transport Triglyceride Transport Plasma Lipoprotein Particle Assembly Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Cholesterol Homeostasis Ceramide 1-phosphate Transport	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Protein Transport Cytokine-mediated Signaling Pathway Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Sequestering Of Calcium Ion Cellular Response To ATP
Pathways		VLDL assembly Chylomicron assembly	Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs		Hesperetin Implitapide Lomitapide	Rifabutin 2-Chlorodideoxyadenosine Geldanamycin 1-Methoxy-2-(2-Methoxyethoxy)Ethane N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases		Abetalipoproteinemia; Bassen-Kornzweig Disease
GWAS		Celiac disease ( 23936387) HDL cholesterol ( 30275531) Regular attendance at a pub or social club ( 29970889)	Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		2 interacting genes: APOB HSP90B1	28 interacting genes: APOB ASGR1 BIRC2 CACYBP CCT2 CSNK2A1 CSNK2A2 EGFR ERBB2 ESR1 FANCC HSPA9 LRP1 MAPK6 MDM2 MTTP NKX3-1 OS9 POLR2E PTPN11 SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11
Entrez ID		4547	7184
HPRD ID		01144	01860
Ensembl ID		ENSG00000138823	ENSG00000166598
Uniprot IDs		B7Z7X3 E9PBP6 P55157	P14625 V9HWP2
PDB IDs			4NH9
Enriched GO Terms of Interacting Partners?
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