TLE4 and PAX5

Number of citations of the paper that reports this interaction (PubMedID 10811620)
71

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TLE4	PAX5
Description		TLE family member 4, transcriptional corepressor	paired box 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Beta-catenin-TCF Complex	Nuclear Chromatin Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Molecular_function Chromatin Binding Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Biological_process Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Humoral Immune Response Multicellular Organism Development Spermatogenesis Aging Animal Organ Morphogenesis Lateral Ventricle Development Cerebral Cortex Development Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	RUNX1 regulates transcription of genes involved in BCR signaling
Drugs
Diseases			Lymphoplasmacytic lymphoma
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Asthma (childhood onset) ( 19714205) Chronotype ( 30696823) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Lymphocyte counts ( 27863252) Motion sickness ( 25628336) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Type 2 diabetes ( 22885922 24509480 30297969 26818947 30718926 28869590)	Alzheimer's disease ( 30636644) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)
Interacting Genes		9 interacting genes: BRCA1 CUX1 LIG4 MSX1 OTX1 OTX2 PAX5 POU2F1 SRPK2	16 interacting genes: CREBBP DAXX EBF1 EP300 ETS1 ID2 ID3 KPNA1 KPNA2 MAPK1 MYB RB1 RUNX1 TBP TLE4 UBE3A
Entrez ID		7091	5079
HPRD ID		05502	01334
Ensembl ID		ENSG00000106829	ENSG00000196092
Uniprot IDs		Q04727	C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548
PDB IDs			1K78 1MDM
Enriched GO Terms of Interacting Partners?
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