TLE4 and CUX1

Number of citations of the paper that reports this interaction (PubMedID 19332113)
15

Data Source:
BioGRID (pull down)

		TLE4	CUX1
Description		TLE family member 4, transcriptional corepressor	cut like homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Beta-catenin-TCF Complex	Golgi Membrane Nucleus Nucleoplasm Golgi Apparatus Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Molecular_function Chromatin Binding Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Protein Binding, Bridging Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Biological_process Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Retrograde Transport, Vesicle Recycling Within Golgi Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Golgi Vesicle Transport Positive Regulation Of Dendrite Morphogenesis
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Asthma (childhood onset) ( 19714205) Chronotype ( 30696823) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Lymphocyte counts ( 27863252) Motion sickness ( 25628336) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Type 2 diabetes ( 22885922 24509480 30297969 26818947 30718926 28869590)	Attention deficit hyperactivity disorder symptom score ( 27663945) Basal cell carcinoma ( 31174203 27539887) Breast cancer ( 29059683) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Intelligence (MTAG) ( 29326435) Keratinocyte cancer (MTAG) ( 31174203) Mean platelet volume ( 27863252) Morning person ( 30696823) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Response to antidepressants ( 22584459) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		9 interacting genes: BRCA1 CUX1 LIG4 MSX1 OTX1 OTX2 PAX5 POU2F1 SRPK2	21 interacting genes: BIN1 CA12 CCNA1 CDC25A CDK1 CDK7 CREBBP CTSL CYTH2 EHMT2 ELAC2 GOLGA5 HMGB1 KAT2B MAX RB1 RECQL5 SATB1 SDC3 SUMO2 TLE4
Entrez ID		7091	1523
HPRD ID		05502	00295
Ensembl ID		ENSG00000106829	ENSG00000257923
Uniprot IDs		Q04727	P39880 Q13948 Q3LIA3
PDB IDs
Enriched GO Terms of Interacting Partners?
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