C1QBP and HMGB1

Number of citations of the paper that reports this interaction (PubMedID 29721183)
2

Data Source:
BioGRID (two hybrid)

		C1QBP	HMGB1
Description		complement C1q binding protein	high mobility group box 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse	Nuclear Chromatin Condensed Chromosome Extracellular Region Extracellular Space Cell Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Cell Surface Transcriptional Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Complement Component C1q Binding Transcription Corepressor Activity MRNA Binding Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Translation Activator Activity Kininogen Binding Adrenergic Receptor Binding Mitochondrial Ribosome Binding	Four-way Junction DNA Binding Bubble DNA Binding Lipopolysaccharide Binding Phosphatidylserine Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Cytokine Activity Integrin Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Lyase Activity C-X-C Chemokine Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding RAGE Receptor Binding DNA Polymerase Binding Repressing Transcription Factor Binding Supercoiled DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway Blood Coagulation, Intrinsic Pathway RNA Splicing Phosphatidylinositol 3-kinase Signaling Viral Process Regulation Of Complement Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis	Negative Regulation Of Transcription By RNA Polymerase II Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Topological Change Apoptotic DNA Fragmentation DNA Recombination Chromatin Remodeling Chromatin Silencing Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Autophagy Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Signaling Receptor Activity Positive Regulation Of Autophagy Viral Process Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Neuron Projection Development Regulation Of Restriction Endodeoxyribonuclease Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Developmental Process Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Interleukin-1 Secretion Positive Regulation Of Interleukin-1 Beta Secretion Positive Chemotaxis DNA Ligation Involved In DNA Repair Positive Regulation Of DNA Ligation Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Neutrophil Clearance Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Interferon-alpha Secretion Positive Regulation Of Vascular Endothelial Cell Proliferation Tumor Necrosis Factor Secretion Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Dendritic Cell Differentiation
Pathways		Apoptotic factor-mediated response Intrinsic Pathway of Fibrin Clot Formation Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	Apoptosis induced DNA fragmentation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs		Hyaluronic acid Copper	Ethyl pyruvate
Diseases
GWAS		Rheumatoid arthritis ( 30423114 24390342)	Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		26 interacting genes: C1QA CEBPA COIL EXOSC6 GAB1 GABRB1 HABP4 HMGB1 HMGB2 HNRNPD HRK MAPK1 MAPK3 MMP14 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SRSF1 SRSF9 TOP3B YWHAB YWHAG	94 interacting genes: ACBD3 AGER AGTRAP AR ATOH1 C1QBP C3 CASP3 CCAR1 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DNM2 DNMT1 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FOXA3 FOXC1 GTF2A1 HES1 HMGA1 HNRNPK HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MECP2 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PTPRZ1 RAD23B RAG1 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 SIX5 SOX18 SPINT1 TAF1 TBP TERF2 TERF2IP TFE3 TGIF1 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBE2I UNC119 ZFP36 ZNF24 ZNF428
Entrez ID		708	3146
HPRD ID		03168	01228
Ensembl ID		ENSG00000108561	ENSG00000189403
Uniprot IDs		Q07021	A0A024RDR0 P09429
PDB IDs		1P32 3RPX	2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM
Enriched GO Terms of Interacting Partners?
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