THOP1 and AGTR1

Number of citations of the paper that reports this interaction (PubMedID 15376229)
4

Data Source:
HPRD (two hybrid, in vitro)

		THOP1	AGTR1
Description		thimet oligopeptidase 1	angiotensin II receptor type 1
Image
GO Annotations	Cellular Component	Mitochondrial Intermembrane Space Cytosol	Cell Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Metalloendopeptidase Activity Peptide Binding Metal Ion Binding	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Protein Polyubiquitination Proteolysis Peptide Metabolic Process	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Blood Vessel Diameter By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Regulation Of Vasoconstriction Calcium-mediated Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of NAD(P)H Oxidase Activity Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Blood Vessel Diameter Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Candesartan
Diseases			Renal tubular dysgenesis
GWAS		Total cholesterol levels ( 28334899)	Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)
Interacting Genes		7 interacting genes: AGTR1 CALM1 MPHOSPH6 MPP6 PRKACA STK11 TRAF2	21 interacting genes: ACADM AGT AGTRAP ARRB1 ARRB2 BDKRB2 DNAJC14 EGFR GPRASP1 GRK2 GRK3 GRK5 HRAS JAK2 NOS3 PDE6H PLCG1 PTGFR RAB5A RAF1 THOP1
Entrez ID		7064	185
HPRD ID		03072	00107
Ensembl ID		ENSG00000172009	ENSG00000144891
Uniprot IDs		P52888	A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5
PDB IDs		1S4B 2O36	1ZV0 4YAY 4ZUD 6DO1
Enriched GO Terms of Interacting Partners?
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