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THBS1 and FN1
Number of citations of the paper that reports this interaction (PubMedID
11773026
)
46
Data Source:
HPRD
(in vitro)
THBS1
FN1
Description
thrombospondin 1
fibronectin 1
Image
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
External Side Of Plasma Membrane
Cell Surface
Sarcoplasmic Reticulum
Secretory Granule
Extracellular Matrix
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Extracellular Region
Fibrinogen Complex
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Molecular Function
Phosphatidylserine Binding
Fibronectin Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Fibroblast Growth Factor Binding
Low-density Lipoprotein Particle Binding
Identical Protein Binding
Laminin Binding
Proteoglycan Binding
Transforming Growth Factor Beta Binding
Fibrinogen Binding
Collagen V Binding
Protease Binding
Signaling Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Protein C-terminus Binding
Heparin Binding
Peptidase Activator Activity
Enzyme Binding
Identical Protein Binding
Proteoglycan Binding
Chaperone Binding
Disordered Domain Specific Binding
Biological Process
Activation Of MAPK Activity
Response To Hypoxia
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Chronic Inflammatory Response
Platelet Degranulation
Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Negative Regulation Of Dendritic Cell Antigen Processing And Presentation
Inflammatory Response
Immune Response
Response To Unfolded Protein
Cell Cycle Arrest
Cell Adhesion
Positive Regulation Of Cell Proliferation
Response To Mechanical Stimulus
Response To Glucose
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Negative Regulation Of Nitric Oxide Mediated Signal Transduction
Negative Regulation Of CGMP-mediated Signaling
Negative Regulation Of Plasminogen Activation
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Cell Migration
Negative Regulation Of Angiogenesis
Peptide Cross-linking
Positive Regulation Of Blood Coagulation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Magnesium Ion
Response To Progesterone
Negative Regulation Of Interleukin-12 Production
Positive Regulation Of Transforming Growth Factor Beta1 Production
Response To Testosterone
Cellular Response To Heat
Response To Endoplasmic Reticulum Stress
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Response To Drug
Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
Positive Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Engulfment Of Apoptotic Cell
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Behavioral Response To Pain
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Chemotaxis
Response To Calcium Ion
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Fibrinolysis
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Endothelial Cell Chemotaxis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Angiogenesis
Regulation Of Protein Phosphorylation
Platelet Degranulation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Calcium-independent Cell-matrix Adhesion
Positive Regulation Of Cell Proliferation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidase Activity
Peptide Cross-linking
Cytokine-mediated Signaling Pathway
Extracellular Matrix Organization
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Wound Healing
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Axon Extension
Positive Regulation Of Fibroblast Proliferation
Leukocyte Migration
Interaction With Symbiont
Regulation Of ERK1 And ERK2 Cascade
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Negative Regulation Of Transforming Growth Factor-beta Secretion
Pathways
Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
Syndecan interactions
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Platelet degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Extracellular matrix organization
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Interleukin-4 and Interleukin-13 signaling
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates PTK2 signaling
Post-translational protein phosphorylation
Signaling downstream of RAS mutants
Drugs
Zinc
Ocriplasmin
Diseases
GWAS
Logical memory (immediate recall) in normal cognition (
29274321
)
Urate levels (
31578528
)
Blood protein levels (
30072576
28240269
)
Cholesterol, total (
26780889
)
Coronary artery disease (
29212778
28714974
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
30578418
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
28334899
)
Negative urgency (
30718321
)
Pulse pressure (
28135244
27841878
30578418
)
Systolic blood pressure (
27841878
30578418
)
Total cholesterol levels (
28334899
)
Interacting Genes
40 interacting genes:
CALCR
CALR
CD36
CD47
CFH
COL1A1
COL2A1
COL3A1
COL4A1
COL5A1
COL7A1
CORO1A
CTSG
DCN
DHFR
ELANE
F2
FGA
FGF2
FN1
HRG
IGFBP5
ITGB3
JAG1
KNG1
LAMB3
LRP1
LRP2
LRP5
MMP2
MMP9
MTDH
PDGFB
PLG
SCARB2
SPARC
TFPI
TGFB1
TNFAIP6
TNFRSF11B
103 interacting genes:
ADAMTS4
AMBP
ANOS1
APCS
ATXN10
ATXN7
C1QA
CCN3
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COMP
CRP
CTSD
CXCL12
DCN
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HRG
HSPG2
IGFBP3
IGFBP5
ITGA2B
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MTDH
MTNR1A
MYOC
NPTX1
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
SCGB1A1
SDC2
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TIMD4
TMPRSS6
TNC
TNFRSF11B
TSHR
UBQLN1
VEGFA
VHL
Entrez ID
7057
2335
HPRD ID
01765
00626
Ensembl ID
ENSG00000137801
ENSG00000115414
Uniprot IDs
P07996
B7ZLE5
P02751
Q6MZF4
Q6MZM7
Q6N084
Q9UQS6
PDB IDs
1LSL
1UX6
1Z78
1ZA4
2ERF
2ES3
2OUH
2OUJ
3R6B
5FOE
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2MNU
2N1K
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
4LXO
4MMX
4MMY
4MMZ
4PZ5
5DC0
5DC4
5DC9
5DFT
5J6Z
5J7C
5M0A
5N47
5N48
6HNF
6MFA
6MSV
Enriched GO Terms of Interacting Partners
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