FN1 and LPA

  • Number of citations of the paper that reports this interaction (PubMedID 2531657)
  • 8
  • Data Source:
  • HPRD (in vivo, in vitro)

FN1

LPA

Description fibronectin 1 lipoprotein(a)
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Aortic valve stenosis ( 29511194)
  • Aortic-valve calcification ( 23388002)
  • Blood protein levels ( 28240269)
  • Body mass index ( 26426971)
  • Body mass index (age>50) ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Cholesterol, total ( 24097068 28270201 25961943 20686565)
  • Coronary artery disease ( 29212778 24262325 30104761 26343387 28714974)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Coronary artery disease in diabetes ( 30003307)
  • Coronary artery disease or ischemic stroke ( 24262325)
  • Coronary artery disease or large artery stroke ( 24262325)
  • Coronary heart disease ( 19198611 21378990)
  • End stage renal disease x APOL1 genotype interaction ( 29885931)
  • HDL cholesterol ( 25961943 20686565)
  • HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Heart failure ( 31919418)
  • Ischemic stroke (large artery atherosclerosis) ( 29531354)
  • LDL cholesterol ( 24097068 30275531 25961943 20686565)
  • LDL cholesterol levels in current drinkers ( 30698716)
  • LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Lipid or lipoprotein levels ( 23696881)
  • Lipoprotein (a) levels ( 26377243 30108283 28512139)
  • Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284)
  • Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643)
  • Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139)
  • Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302)
  • Lp (a) levels ( 21900290 19124843)
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401)
  • Medication use (antithrombotic agents) ( 31015401)
  • Medication use (beta blocking agents) ( 31015401)
  • Medication use (HMG CoA reductase inhibitors) ( 31015401)
  • Medication use (salicylic acid and derivatives) ( 31015401)
  • Medication use (vasodilators used in cardiac diseases) ( 31015401)
  • Metabolic syndrome ( 31589552)
  • Metabolite levels (lipoprotein measures) ( 27005778)
  • Minimum ankle–brachial index ( 31285632)
  • Monocyte early outgrowth colony forming units ( 21493818)
  • Myocardial infarction ( 26343387)
  • Parental lifespan ( 29030599)
  • Parental longevity (both parents in top 10%) ( 29227965)
  • Parental longevity (combined parental age at death) ( 29227965)
  • Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
  • Parental longevity (father's age at death) ( 31484785 29227965)
  • Parental longevity (father's attained age) ( 29227965)
  • Parental longevity (mother's age at death or mother's attained age) ( 31484785)
  • Parental longevity (mother's age at death) ( 29227965)
  • Parental longevity (mother's attained age) ( 29227965)
  • Peripheral artery disease ( 31285632)
  • Plasma plasminogen levels ( 25208887)
  • Protein quantitative trait loci ( 18464913)
  • Response to statin therapy ( 22368281)
  • Response to statins (LDL cholesterol change) ( 25350695 22331829)
  • Total cholesterol levels ( 28334899 30275531)
  • Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Triglycerides ( 30275531 25961943)
Interacting Genes 103 interacting genes: ADAMTS4 AMBP ANOS1 APCS ATXN10 ATXN7 C1QA CCN3 CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA2B ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MTDH MTNR1A MYOC NPTX1 NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TIMD4 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VEGFA VHL 9 interacting genes: APOH CANX CELA1 ELANE FBLN5 FGB FN1 LRP2 MMP12
Entrez ID 2335 4018
HPRD ID 00626 01063
Ensembl ID ENSG00000115414 ENSG00000198670
Uniprot IDs B7ZLE5 P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6
PDB IDs 1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48 6HNF 6MFA 6MSV
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?