THBD and PSENEN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		THBD	PSENEN
Description		thrombomodulin	presenilin enhancer, gamma-secretase subunit
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GO Annotations	Cellular Component	Extracellular Space Vacuolar Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apicolateral Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding Signaling Receptor Activity	Protein Binding
	Biological Process	Female Pregnancy Blood Coagulation Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Response To Lipopolysaccharide Leukocyte Migration Response To CAMP Negative Regulation Of Fibrinolysis	Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs		Drotrecogin alfa Ibuprofen Dexibuprofen	E-2012
Diseases		Inherited thrombophilia	Acne inversa; Hidradenitis supprativa
GWAS		Blood protein levels in cardiovascular risk ( 28369058) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Venous thromboembolism ( 26888256)
Interacting Genes		6 interacting genes: F2 LMNA PF4 PROC PSENEN SERPINA5	7 interacting genes: APH1A CREB3 NCSTN PSEN1 PSEN2 THBD TMED10
Entrez ID		7056	55851
HPRD ID		01764	06362
Ensembl ID		ENSG00000178726	ENSG00000205155
Uniprot IDs		P07204	Q9NZ42
PDB IDs		1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS 5TO3	5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC
Enriched GO Terms of Interacting Partners?
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