THBD and PF4

Number of citations of the paper that reports this interaction (PubMedID 9395524)
6

Data Source:
HPRD (in vitro)

		THBD	PF4
Description		thrombomodulin	platelet factor 4
Image
GO Annotations	Cellular Component	Extracellular Space Vacuolar Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apicolateral Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm Symbiont-containing Vacuole Membrane Host Cell Cytoplasm Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding Signaling Receptor Activity	Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding
	Biological Process	Female Pregnancy Blood Coagulation Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Response To Lipopolysaccharide Leukocyte Migration Response To CAMP Negative Regulation Of Fibrinolysis	Platelet Degranulation Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Leukocyte Chemotaxis Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall	Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Drotrecogin alfa Ibuprofen Dexibuprofen	Drotrecogin alfa Heparin
Diseases		Inherited thrombophilia
GWAS		Blood protein levels in cardiovascular risk ( 28369058) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Venous thromboembolism ( 26888256)	Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		6 interacting genes: F2 LMNA PF4 PROC PSENEN SERPINA5	11 interacting genes: CCL5 CXCL12 CXCL8 CXCR3 FGF2 LDLR PROC SDC2 SRGN THBD VCAN
Entrez ID		7056	5196
HPRD ID		01764	01426
Ensembl ID		ENSG00000178726	ENSG00000163737
Uniprot IDs		P07204	P02776
PDB IDs		1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS 5TO3	1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU
Enriched GO Terms of Interacting Partners?
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