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TGFBR2 and SMAD4
Number of citations of the paper that reports this interaction (PubMedID
8774881
)
193
Data Source:
HPRD
(in vitro)
TGFBR2
SMAD4
Description
transforming growth factor beta receptor 2
SMAD family member 4
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
External Side Of Plasma Membrane
Integral Component Of Membrane
Receptor Complex
Membrane Raft
Nuclear Chromatin
Cell
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Centrosome
Cytosol
Activin Responsive Factor Complex
SMAD Protein Complex
Molecular Function
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type II
Protein Binding
ATP Binding
Glycosaminoglycan Binding
Activin-activated Receptor Activity
Mitogen-activated Protein Kinase Kinase Kinase Binding
Type I Transforming Growth Factor Beta Receptor Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Proximal Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Transcription Coregulator Activity
Protein Binding
Collagen Binding
Transforming Growth Factor Beta Receptor, Common-partner Cytoplasmic Mediator Activity
Identical Protein Binding
Protein Homodimerization Activity
Sulfate Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Metal Ion Binding
I-SMAD Binding
R-SMAD Binding
Molecular Function Regulator
Biological Process
Blood Vessel Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Response To Hypoxia
In Utero Embryonic Development
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Tolerance Induction To Self Antigen
Positive Regulation Of B Cell Tolerance Induction
Positive Regulation Of T Cell Tolerance Induction
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Outflow Tract Morphogenesis
Atrioventricular Valve Morphogenesis
Tricuspid Valve Morphogenesis
Cardiac Left Ventricle Morphogenesis
Endocardial Cushion Fusion
Growth Plate Cartilage Chondrocyte Growth
Protein Phosphorylation
Receptor-mediated Endocytosis
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
Notch Signaling Pathway
Smoothened Signaling Pathway
Gastrulation
Brain Development
Heart Development
Embryo Implantation
Aging
Response To Nutrient
Positive Regulation Of Cell Proliferation
Response To Mechanical Stimulus
Response To Glucose
Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Animal Organ Regeneration
Activation Of Protein Kinase Activity
Activin Receptor Signaling Pathway
Embryonic Hemopoiesis
Wound Healing
Regulation Of Cell Proliferation
Response To Drug
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Skeletal Muscle Tissue Regeneration
Response To Estrogen
Positive Regulation Of Angiogenesis
Response To Steroid Hormone
Digestive Tract Development
Positive Regulation Of Smooth Muscle Cell Proliferation
Embryonic Cranial Skeleton Morphogenesis
Positive Regulation Of NK T Cell Differentiation
Negative Regulation Of Cardiac Muscle Cell Proliferation
Pathway-restricted SMAD Protein Phosphorylation
Ventricular Septum Morphogenesis
Bronchus Morphogenesis
Trachea Formation
Mammary Gland Morphogenesis
Lung Lobe Morphogenesis
Secondary Palate Development
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cell Proliferation Involved In Endocardial Cushion Morphogenesis
Superior Endocardial Cushion Morphogenesis
Inferior Endocardial Cushion Morphogenesis
Lens Fiber Cell Apoptotic Process
MiRNA Transport
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Branching Involved In Ureteric Bud Morphogenesis
Response To Hypoxia
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Outflow Tract Septum Morphogenesis
Atrioventricular Valve Formation
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Brainstem Development
Cellular Iron Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Spermatogenesis
Single Fertilization
Axon Guidance
Cell Proliferation
Negative Regulation Of Cell Proliferation
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Neural Crest Cell Differentiation
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Growth
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Somite Rostral/caudal Axis Specification
Regulation Of Transforming Growth Factor Beta2 Production
Positive Regulation Of Luteinizing Hormone Secretion
Somatic Stem Cell Population Maintenance
Intracellular Signal Transduction
Atrioventricular Canal Development
Endothelial Cell Activation
Embryonic Digit Morphogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Follicle-stimulating Hormone Secretion
Mesendoderm Development
Developmental Growth
Neuron Fate Commitment
Sebaceous Gland Development
Formation Of Anatomical Boundary
Regulation Of Binding
Positive Regulation Of Histone H3-K4 Methylation
Regulation Of Hair Follicle Development
Uterus Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Negative Regulation Of Cell Death
Endocardial Cell Differentiation
Female Gonad Morphogenesis
Pri-miRNA Transcription By RNA Polymerase II
Secondary Palate Development
Interleukin-6-mediated Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Response To Transforming Growth Factor Beta
Cellular Response To BMP Stimulus
Metanephric Mesenchyme Morphogenesis
Nephrogenic Mesenchyme Morphogenesis
Seminiferous Tubule Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Negative Regulation Of Cardiac Myofibril Assembly
Positive Regulation Of Histone H3-K9 Acetylation
Pathways
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
Signaling by NODAL
Signaling by Activin
Signaling by BMP
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
RUNX2 regulates bone development
RUNX3 regulates CDKN1A transcription
RUNX3 regulates BCL2L11 (BIM) transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Drugs
Glycerin
Diseases
Colorectal cancer
Loeys-Dietz syndrome (LDS)
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
Colorectal cancer
Hereditary hemorrhagic telangiectasia (HHT)
Pancreatic cancer
Juvenile polyposis syndrome
GWAS
Breast cancer (
29059683
23535729
)
Cellular nuclear factor (erythroid-derived 2)-like 2 levels (
30767168
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
Migraine (
22683712
27322543
)
Migraine - clinic-based (
23793025
)
Night sleep phenotypes (
27126917
)
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) (
25117820
)
Systolic blood pressure (
30224653
)
Tonometry (
17903302
)
Asthma (
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Immune response to anthrax vaccine (
22658931
)
Metabolite levels (
23823483
)
Oligoclonal band status in multiple sclerosis (
25616667
)
Interacting Genes
46 interacting genes:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CBL
CCNB1
CCNB2
CD44
CDK1
CLU
CTNNB1
DAB2
DAXX
EIF3I
ENG
GOPC
KCNK18
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
PSMD14
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TCTEX1D4
TDGF1
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TSSK1B
ZFYVE9
189 interacting genes:
ACVR1B
AKT1
AP2B1
APBB2
AR
ARFRP1
ARL5B
ATF2
ATF7IP
BCAS3
BEX1
BRCA1
BTRC
CAMK2G
CD59
CEBPA
CEBPB
CEBPD
CHEK1
CITED1
CNKSR1
COPS5
CREBBP
CSH1
CSH2
CTCF
CTNNB1
CYFIP2
DACH1
DCP1A
DCP1B
DKK3
DLX1
DNAJB2
DNMT3L
DVL1
ECSIT
EEF1A1
EID2
EIF2AK4
EP300
ERBIN
ESR1
ESR2
EWSR1
FBLN1
FBXO30
FBXO34
FHL2
FHL3
FN1
FOXG1
FOXH1
FOXO1
FOXO3
FOXO4
FSTL3
GATA2
GLI3
GPNMB
GREB1
HDGF
HDLBP
HMG20A
HNF4A
HOXA9
HOXC8
HYAL2
IL24
ITK
JUN
JUNB
JUND
LEF1
LMO4
LRATD2
LYPD3
MAPK1
MAPK13
MAX
MDM4
MECOM
MEF2A
MEX3B
MYOD1
NAT8
NEK6
NELFCD
NFIA
NKX3-2
NOTCH4
NR0B2
NRAS
NUAK2
NUP214
OTUB1
PAK1
PAPPA2
PARD3
PBK
PIAS1
PIAS2
PIAS3
PIAS4
PLG
PLK4
PRKAR1B
PRKAR2A
PRPF40A
PSG2
PSG9
PSMD11
RAB13
RAB25
RAB2B
RAB34
RAB38
RAB3B
RAC2
RALA
RASD2
RASL12
RASSF5
RBL1
RELA
RFX1
RHEBL1
RHOD
RHOG
RHOJ
RIPK2
RMND5B
RPL28
RPS27A
RRAS2
RSPH14
S100A14
SASH3
SERPINA1
SERPINB5
SKI
SKIL
SKP2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD7
SMAD9
SNIP1
SNRNP70
SNW1
SOX12
SP1
SPTBN1
SQSTM1
STK11IP
STK35
STUB1
TCTA
TDG
TENM3
TFE3
TGFBR1
TGFBR2
TGFBRAP1
THRSP
TIAF1
TM9SF2
TOB1
TRAP1
TSSK3
UBA52
UBB
UBE2I
UBE2L3
UBE2Z
UHRF2
USB1
USP4
USP9X
WWOX
XPO5
ZBED5
ZBTB7A
ZMYM2
ZNF423
ZNF521
ZNF8
Entrez ID
7048
4089
HPRD ID
01823
02995
Ensembl ID
ENSG00000163513
ENSG00000141646
Uniprot IDs
A3QNQ0
D2JYI1
P37173
A0A024R274
Q13485
PDB IDs
1KTZ
1M9Z
1PLO
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5QIN
5TX4
5TY4
1DD1
1G88
1MR1
1U7F
1U7V
1YGS
5C4V
5MEY
5MEZ
5MF0
5UWU
Enriched GO Terms of Interacting Partners
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