TGFA and SGTA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TGFA	SGTA
Description		transforming growth factor alpha	small glutamine rich tetratricopeptide repeat containing alpha
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Membrane TRC Complex Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Binding Identical Protein Binding Protein Self-association Molecular Adaptor Activity BAT3 Complex Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Regulation Of Transcription By RNA Polymerase II ER To Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division COPII Vesicle Coating Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Membrane Organization	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Viral Process Ubiquitin-dependent ERAD Pathway Chaperone-mediated Protein Folding Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Protein Folding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Gastric cancer
GWAS		Acne (severe) ( 24927181) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Hair shape ( 29220522) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549) Hip minimal joint space width ( 27701424) Longevity ( 20834067) Neutrophil count ( 21507922) Obesity-related traits ( 23251661) Osteoarthritis ( 30664745) Pulse pressure in young-onset hypertension ( 24892410) Response to citalopram or escitalopram in depression ( 27622933) Severe progression in rheumatoid arthritis ( 29065906) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		15 interacting genes: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 MAGI2 MAGI3 NKD2 RHBDF1 SDCBP SGTA SNTA1	98 interacting genes: ADIPOQ ADRM1 AGR3 BAG6 BCL2L12 BTC C1QA C1QTNF1 C1QTNF6 C3orf52 CD79B CD99 CD99L2 CDH15 COL1A2 COL8A2 CSF1 CST1 CTSL CXCL8 EFEMP1 EFEMP2 ERP27 EVA1B F11R FERD3L FIP1L1 FKBP7 FXYD7 GABARAPL2 GAL GHR GIP GPX7 GRN GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 HSPA8 IGL IGLC1 IRF3 IRF5 ITPRIPL1 KASH5 KRT6A KTN1 LAIR2 LAT MSMB MSTN MYDGF NAXD NME3 NR3C1 NXF1 PBXIP1 PCDHA4 PFN2 PGR PIAS1 PLAAT4 PPIB PPIC PPP1R3C PRAP1 PTN RPN1 SDC4 SERPINE1 SGCA SLPI SMAGP SOD3 SPP1 SPPL2A SRGN SYT11 SYT4 TFF3 TFRC TGFA TMEM174 TMEM31 TMPO TMUB2 TNFRSF13B TNFRSF1A TWSG1 TXNDC12 UBL4A UPK3A VIP WBP1L ZG16 ZG16B
Entrez ID		7039	6449
HPRD ID		07522	04568
Ensembl ID		ENSG00000163235	ENSG00000104969
Uniprot IDs		E7EPT6 F8VNR3 P01135	O43765
PDB IDs		1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF 5KN5	2VYI 4CPG 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?
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