TFAP2A and DEK

Number of citations of the paper that reports this interaction (PubMedID 12595566)
38

Data Source:
HPRD (in vivo, in vitro)

		TFAP2A	DEK
Description		transcription factor AP-2 alpha	DEK proto-oncogene
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Contractile Fiber
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Transcription Coactivator Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	DNA Binding RNA Binding Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Optic Vesicle Morphogenesis Optic Cup Structural Organization Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Retina Layer Formation Negative Regulation Of Transcription By Competitive Promoter Binding Trigeminal Nerve Development Oculomotor Nerve Formation Positive Regulation Of Bone Mineralization Embryonic Forelimb Morphogenesis Regulation Of Cell Proliferation Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Roof Of Mouth Development Bone Morphogenesis Eyelid Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Iron Ion Negative Regulation Of Reactive Oxygen Species Metabolic Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Signal Transduction Viral Genome Replication Positive Regulation Of Gene Expression, Epigenetic Regulation Of Double-strand Break Repair Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	B-WICH complex positively regulates rRNA expression Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs
Diseases		Branchiooculofacial syndrome (BOFS)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Breast cancer in BRCA2 mutation carriers ( 23544012) Glucose homeostasis traits ( 25524916) Iron status biomarkers (ferritin levels) ( 28334935) Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Zinc levels ( 26025379)	Atrial fibrillation ( 30061737) Metabolite levels ( 23823483)
Interacting Genes		37 interacting genes: APC CASP1 CASP3 CASP6 CITED2 CITED4 CLTC CSNK2A1 CSNK2B CTNNB1 DEK EP300 EPN1 EPN2 EPS15 GSTO2 HIP1 KCTD15 LDLRAP1 MAGI1 MKRN3 MYC NFKB1 NPM1 PPARG PRKAA2 PRKD1 RB1 SRA1 SUMO4 SYT1 TP53 UBE2I VEGFA WWP1 WWP2 YBX1	10 interacting genes: AP2A1 CREBBP CSNK2A1 EP300 H3-4 HLA-A KAT2B SRRM1 TFAP2A ZIK1
Entrez ID		7020	7913
HPRD ID		00128	00503
Ensembl ID		ENSG00000137203	ENSG00000124795
Uniprot IDs		P05549	H0Y993 P35659
PDB IDs			1Q1V 2JX3
Enriched GO Terms of Interacting Partners?
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