TERF1 and TCIRG1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		TERF1	TCIRG1
Description		telomeric repeat binding factor 1	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Fibrillar Center Cell Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Nuclear Body Shelterin Complex	Vacuolar Proton-transporting V-type ATPase, V0 Domain Cell Nucleus Lysosomal Membrane Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Ankyrin Repeat Binding G-rich Strand Telomeric DNA Binding	Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Telomere Maintenance Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Response To Drug Meiotic Telomere Clustering Cell Division Negative Regulation Of Telomerase Activity Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Exonuclease Activity Negative Regulation Of Telomeric D-loop Disassembly	Autophagosome Assembly Ossification Osteoclast Proliferation Immunoglobulin Production Cellular Calcium Ion Homeostasis Apoptotic Process Inflammatory Response Cellular Defense Response Vacuolar Acidification Protein Catabolic Process In The Vacuole Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Regulation Of Proton Transport Response To Silver Ion Gene Expression Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Macroautophagy Optic Nerve Development Establishment Of Cell Polarity B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Ruffle Organization Protein Localization To Organelle Transferrin Transport Ion Transmembrane Transport Memory T Cell Activation T-helper 1 Cell Activation T Cell Homeostasis Neutrophil Degranulation Tooth Eruption Bone Resorption Regulation Of Osteoblast Differentiation Regulation Of Insulin Secretion Establishment Of Vesicle Localization Retina Development In Camera-type Eye Hematopoietic Stem Cell Homeostasis Enamel Mineralization Cellular Response To Cytokine Stimulus Interferon-gamma Secretion Phagosome Acidification Dentin Mineralization Proton Transmembrane Transport
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase DNA Damage/Telomere Stress Induced Senescence	ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Crohn's disease ( 22412388) Leukocyte telomere length ( 31171785)	Heel bone mineral density ( 30598549)
Interacting Genes		204 interacting genes: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 ANXA8L1 APEX1 ARHGDIA ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS H1-1 HCLS1 HDGFL2 HEXIM1 HEXIM2 HGD HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KDM1A KEAP1 KIFBP KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MSN MT1X MVK NAP1L1 NBN NEFL NEK7 NME1 NME2 NOL12 NOL3 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS1 SBDS SENP8 SET SH3BP1 SH3GL2 SH3GL3 SHFL SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UBE2M UTP14A WARS1 WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790	4 interacting genes: CYTH2 KCNK1 MTDH TERF1
Entrez ID		7013	10312
HPRD ID		02975	05207
Ensembl ID		ENSG00000147601	ENSG00000110719
Uniprot IDs		P54274	A0A024R5E5 Q13488
PDB IDs		1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82 5HKP 5WIR 5XUP
Enriched GO Terms of Interacting Partners?
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