ELOA and PLK4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ELOA	PLK4
Description		elongin A	polo like kinase 4
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GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Elongin Complex Site Of DNA Damage	Spindle Pole XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cleavage Furrow Deuterosome
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cytokinesis Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS
Interacting Genes		25 interacting genes: BRCA1 CBY2 CEP57L1 CEP70 CUL5 ELOB ERCC6 FAM9B GMCL1 HOMEZ JAKMIP2 KRT40 KRTAP10-3 LMNA MDFI MED21 MID2 NINL PLK4 POLR2A RAD54B RAP1A REXO1 SIRPA TRIM54	12 interacting genes: ARR3 BTRC C1orf109 CHD3 ELOA MTUS2 SFN SMAD4 TAX1BP3 TEC TENT5C TGFBR1
Entrez ID		6924	10733
HPRD ID		02873	10387
Ensembl ID		ENSG00000011007	ENSG00000142731
Uniprot IDs		Q14241	O00444
PDB IDs		4HFX	2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46
Enriched GO Terms of Interacting Partners?
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