PLK4 and C1orf109

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PLK4	C1orf109
Description		polo like kinase 4	chromosome 1 open reading frame 109
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cleavage Furrow Deuterosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cytokinesis Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Axial length ( 24144296) Eyebrow thickness ( 26926045)
Interacting Genes		12 interacting genes: ARR3 BTRC C1orf109 CHD3 ELOA MTUS2 SFN SMAD4 TAX1BP3 TEC TENT5C TGFBR1	46 interacting genes: C1orf94 CBY2 CEP55 CINP CRX CSNK2A1 GOLGA2 IHO1 IKZF1 IKZF3 KATNAL1 KIFC3 KRT13 KRT19 KRT31 KRT40 LDOC1 LZTS2 MAP7D1 MEOX2 MKRN2 MTUS2 NECAB2 PDE4DIP PHC2 PLK4 PPP1R12C REL RINT1 RNF41 SDCBP SPAG5 STX11 TADA2A TCF12 TCF4 TFIP11 TLE5 TRAF1 TRIM27 TRIM42 TRIM54 USHBP1 VPS52 ZBED1 ZNF398
Entrez ID		10733	54955
HPRD ID		10387	07918
Ensembl ID		ENSG00000142731	ENSG00000116922
Uniprot IDs		O00444	B4DRQ5 B7Z9X8 Q9NX04
PDB IDs		2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46
Enriched GO Terms of Interacting Partners?
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