TBL1X and FOXK2

Number of citations of the paper that reports this interaction (PubMedID 25609649)
36

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down)

		TBL1X	FOXK2
Description		transducin beta like 1 X-linked	forkhead box K2
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcriptional Repressor Complex Mitotic Spindle	Nuclear Chromatin Cell Nucleus Nucleoplasm Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding Transcription Regulatory Region DNA Binding	Magnesium Ion Binding Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Histone Deacetylation Regulation Of Lipid Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Cellular Glucose Homeostasis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy Regulation Of Glucose Metabolic Process Protein Deubiquitination Response To Starvation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Canonical Glycolysis
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events	UCH proteinases
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Heel bone mineral density ( 30598549) Lean body mass ( 28552196) Letter-number span reordering ( 31596458) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		28 interacting genes: CDC34 CORO2A CTNNB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I	10 interacting genes: ESR1 HCFC1 IL2 MTA3 RBBP4 RBBP7 RCOR1 SIN3A TBL1X TBL1XR1
Entrez ID		6907	3607
HPRD ID		02183	00982
Ensembl ID		ENSG00000101849	ENSG00000141568
Uniprot IDs		A0A024RBV9 O60907	Q01167
PDB IDs		2XTC 2XTD 2XTE	1JXS 2C6Y
Enriched GO Terms of Interacting Partners?
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