MAP3K7 and SMAD6

  • Number of citations of the paper that reports this interaction (PubMedID 10748100)
  • 57
  • Data Source:
  • BioGRID (affinity chromatography technology, affinity chromatography technology)
  • HPRD (in vivo)

MAP3K7

SMAD6

Description mitogen-activated protein kinase kinase kinase 7 SMAD family member 6
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Amyotrophic lateral sclerosis (sporadic) ( 24529757)
  • Asthma ( 29273806)
  • Asthma (adult onset) ( 31036433)
  • Asthma (childhood onset) ( 31036433)
  • Bone mineral density (hip) ( 30172743)
  • Celiac disease ( 20190752)
  • Graves' disease ( 21841780)
  • Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)
  • Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382)
  • Severity of nausea and vomiting of pregnancy ( 29563502)
  • Asthma ( 29273806)
  • Asthma (adult onset) ( 31036433)
  • Asthma (childhood onset) ( 31036433)
  • Carpal tunnel syndrome ( 30833571)
  • Dental caries (decayed and filled deciduous teeth) ( 31533690)
  • Height ( 31562340)
  • Lung cancer (smoking interaction) ( 24658283)
  • Severe aortic features in Marfan syndrome ( 30087447)
  • Subcutaneous adipose tissue ( 22589738)
  • Waist-hip ratio ( 25673412)
  • Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes 65 interacting genes: BBS10 BCL10 CARD11 CHUK COPS5 CYLD EIF2AK2 ELP1 EZH2 FOS GPR25 HGS HIPK2 IKBKB IKBKG IL17RD IRAK1 MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS MUL1 NAIP NDUFS6 NFKBIA NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB TAB1 TAB2 TGFBR1 TNFRSF11A TRAF3 TRAF3IP2 TRAF6 UBASH3A UBC VRK2 XIAP ZNF593 ZNF746 16 interacting genes: BMPR1B HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1
Entrez ID 6885 4091
HPRD ID 04011 04240
Ensembl ID ENSG00000135341 ENSG00000137834
Uniprot IDs O43318 O43541
PDB IDs 2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5V5N
Enriched GO Terms of Interacting Partners?
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