SYT4 and NBR1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SYT4	NBR1
Description		synaptotagmin 4	NBR1 autophagy cargo receptor
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Golgi Membrane Integral Component Of Synaptic Vesicle Membrane Axon Dendrite Dense Core Granule Membrane Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Exocytic Vesicle Astrocyte Projection Glutamatergic Synapse Neuronal Dense Core Vesicle Integral Component Of Neuronal Dense Core Vesicle Membrane Microvesicle	Phagophore Assembly Site Nucleoplasm Mitochondrion Lysosome Late Endosome Autophagosome Cytosol Membrane Nuclear Body M Band Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Syntaxin-1 Binding Clathrin Binding Syntaxin-3 Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding Zinc Ion Binding Ubiquitin Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Vesicle Fusion Neurotransmitter Secretion Brain Development Memory Positive Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium Ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Endocytosis Negative Regulation Of Vesicle Fusion Negative Regulation Of Catecholamine Secretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity Negative Regulation Of Protein Secretion Vesicle Fusion With Vesicle Secretory Granule Maturation Cellular Response To Calcium Ion Regulation Of Presynaptic Dense Core Granule Exocytosis Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Dense Core Granule Cytoskeletal Transport Positive Regulation Of Dendrite Extension Negative Regulation Of Dense Core Granule Exocytosis Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Negative Regulation Of Synaptic Vesicle Exocytosis	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation
Pathways			Pexophagy Pexophagy
Drugs
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Body mass index ( 28892062 25673413) Coffee consumption ( 31046077) Metabolite levels ( 23823483) Parkinson's disease ( 28892059 21738487) Physical activity (moderate intensity activity duration) ( 30531941) Physical activity (overall physical activity time) ( 30531941) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Pulse pressure ( 27841878) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27841878)
Interacting Genes		10 interacting genes: NBR1 NRXN1 SGTA STX1A STX2 STX3 STX4 SYNCRIP SYT1 TFAP2B	21 interacting genes: ATXN1L AXIN1 CALM1 CIB1 FEZ1 GABARAP GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A MAP1LC3B MAP2K4 SQSTM1 SYT4 TTN UBC UBE2D2 UBE2D3 USP8 VTA1
Entrez ID		6860	4077
HPRD ID		02519	01326
Ensembl ID		ENSG00000132872	ENSG00000188554
Uniprot IDs		Q9H2B2	A0A024R1V3 B7Z5R6 Q14596
PDB IDs		1UGK	1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE
Enriched GO Terms of Interacting Partners?
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