SYP and AP1G1

Number of citations of the paper that reports this interaction (PubMedID 12498786)
9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		SYP	AP1G1
Description		synaptophysin	adaptor related protein complex 1 subunit gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Synaptic Vesicle Cell Junction Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Neuron Projection Terminal Bouton Perinuclear Region Of Cytoplasm Presynaptic Active Zone Excitatory Synapse Schaffer Collateral - CA1 Synapse	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Cholesterol Binding Syntaxin-1 Binding SH2 Domain Binding Identical Protein Binding Protein Self-association	Protein Binding Rab GTPase Binding Kinesin Binding GTP-dependent Protein Binding
	Biological Process	Endocytosis Synaptic Vesicle Maturation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Membrane Organization Cellular Response To Organic Substance Regulation Of Synaptic Vesicle Exocytosis Regulation Of Opioid Receptor Signaling Pathway	Intracellular Protein Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus By Virus Golgi To Lysosome Transport
Pathways			Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS			General cognitive ability ( 29844566) Post bronchodilator FEV1 ( 26634245) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		6 interacting genes: AP1G1 GAB1 GRB2 SIAH1 SIAH2 VAMP2	24 interacting genes: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 ARFRP1 BAALC CLINT1 CLTC DNER EPS15 KIF13A MAP1A PSEN2 RABEP1 RABGEF1 SPTB SYNRG SYP UBL7 UPF1 ZNF512B
Entrez ID		6855	164
HPRD ID		02435	04637
Ensembl ID		ENSG00000102003	ENSG00000166747
Uniprot IDs		P08247	A0A140VJE7 O43747 Q8IY97
PDB IDs			1IU1
Enriched GO Terms of Interacting Partners?
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