STAT3 and KRTAP10-7

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		STAT3	KRTAP10-7
Description		signal transducer and activator of transcription 3	keratin associated protein 10-7
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane Postsynaptic Density RNA Polymerase II Transcription Factor Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Cytosol Keratin Filament
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Phosphatase Binding Chromatin DNA Binding CCR5 Chemokine Receptor Binding Glucocorticoid Receptor Binding Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Dimerization Activity	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Temperature Homeostasis Eye Photoreceptor Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Defense Response Acute-phase Response Inflammatory Response Signal Transduction JAK-STAT Cascade Nervous System Development Aging Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sexual Reproduction Positive Regulation Of Cell Migration Intracellular Receptor Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Leptin-mediated Signaling Pathway Somatic Stem Cell Population Maintenance MiRNA Mediated Inhibition Of Translation Interleukin-15-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Eating Behavior MRNA Transcription By RNA Polymerase II Response To Peptide Hormone Cellular Response To Leptin Stimulus Response To Leptin Positive Regulation Of Interleukin-6 Biosynthetic Process Response To Ethanol Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitochondrial Membrane Permeability Astrocyte Differentiation Modulation Of Chemical Synaptic Transmission Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Cycle Radial Glial Cell Differentiation Regulation Of Feeding Behavior Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Organic Cyclic Compound T-helper 17 Cell Lineage Commitment Energy Homeostasis Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Neuron Death Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Gene Silencing By MiRNA Negative Regulation Of Stem Cell Differentiation Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Neuron Migration	Keratinization
Pathways		Interleukin-6 signaling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signalling to STAT3 Senescence-Associated Secretory Phenotype (SASP) Signaling by Leptin POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Association of TriC/CCT with target proteins during biosynthesis Transcriptional regulation of pluripotent stem cells Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling PTK6 Activates STAT3 PTK6 Activates STAT3 Interleukin-20 family signaling MET activates STAT3 MET activates STAT3 Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-37 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-21 signaling Transcriptional regulation of granulopoiesis Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Growth hormone receptor signaling	Keratinization
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) Oral cancer
GWAS		Atopic dermatitis ( 26482879) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 18587394 28067908 21102463 23266558) Diastolic blood pressure ( 30578418) Inflammatory bowel disease ( 27569725 28067908 26278503 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular volume ( 27863252) Multiple sclerosis ( 31604244 22190364 24076602 21833088 20159113) Psoriasis ( 25903422 23143594) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458) Ulcerative colitis ( 28067908)
Interacting Genes		203 interacting genes: ABL2 ADRB2 AMBP AR ARFIP2 ASXL1 ATF3 BATF3 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 BRWD1 CA8 CAPN1 CAPNS1 CBL CCDC87 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CHTF18 CNDP2 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX DOK2 DOK3 DTNA ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBIN FAM117B FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GATA1 GATA2 GHR GNL3 GSTCD GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HESX1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KLF15 KPNA1 KPNA6 KRTAP10-7 LAMB2 LASP1 LCK LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MET MNDA MORC4 MPZL1 MRPS31 MTOR MYOD1 NACAD NCOA1 NDUFA13 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 NUFIP2 NXT2 OFCC1 OGDHL PAFAH1B2 PAQR7 PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PIK3R1 PIK3R2 PIK3R3 PINK1 PML PPARD PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RABGAP1 RAC1 RACK1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 RRAD SCAF11 SETD7 SH2D2A SH3BP2 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TASOR2 TDG TM4SF19 TRIM28 TRIP10 TSHR TSLP TWIST1 VPS39 WDFY3 ZFPM2 ZNF148 ZNF281 ZNF467 ZNF557 ZNF829 ZNRD2	217 interacting genes: AEN ALDH3B1 ANKRD36BP1 AP1M1 APP AQP1 AVPI1 B4GALT7 BAHD1 BCL6B BMP7 BUD31 BYSL C19orf57 C8orf33 CARHSP1 CATIP CBX2 CCDC185 CCDC26 CCNG1 CDCA7L CHIC2 CHRD CHRNG CLK1 CLK4 COL8A1 CRCT1 CREB5 CSNK1G1 CSNK1G2 CTNNBIP1 CTRC CXCL16 DAAM2 DERL2 DHX57 DMRT3 E2F6 E4F1 EHHADH FAM124B FAM161A FAM27E3 FAM74A4 FAM76B FARS2 GABARAPL1 GABARAPL2 GEM GLIDR GLP1R GNE GOLGA8EP GRN GSTP1 GUCD1 HBZ HHEX HPCAL1 HSBP1 HSD3B7 IGSF8 ING5 INPP5D IQUB KLHL38 KRT20 KRT83 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE1B LCE2A LCE3E LCE4A LIMS2 LINC00242 LMNA LMO2 LRCH4 MAPKBP1 MCM5 MOBP MRGBP MXD3 MXI1 NAA10 NAXD NECTIN2 NECTIN3 NOL12 NOTCH2NLA NPBWR2 NPDC1 NTAQ1 NUBP2 NUDCD3 NUFIP2 P2RY6 PCED1A PCSK5 PDIA5 PDLIM5 PFKL PGAP6 PIN1 POLL POM121L8P PPARD PRKAB2 PRM2 PRR13 PTGDS PTGER3 PTPMT1 PVR RNF175 RPF1 RPL11 RPL36AL RPS28 RPUSD3 RSPO2 RTN4RL1 RWDD2B SCNM1 SDCBP SHFL SLC23A1 SLC25A48 SLC6A20 SMCO4 SMCP SPACA9 SPATA3 SPATA8 SPG7 SPRY1 SSX2IP STAT3 STK16 SUV39H1 TAPBPL TCEA2 TCEANC TEDC2 THAP1 THAP6 TLE5 TMA16 TNP2 TNS2 TOR1A TREX1 TRIM42 TULP3 TXNDC5 TYRO3 UCP2 UXT VTI1B WNT11 WT1 ZBTB24 ZBTB38 ZBTB9 ZFYVE26 ZNF101 ZNF124 ZNF133 ZNF155 ZNF165 ZNF169 ZNF175 ZNF180 ZNF2 ZNF20 ZNF223 ZNF250 ZNF26 ZNF266 ZNF32 ZNF320 ZNF329 ZNF337 ZNF41 ZNF417 ZNF418 ZNF419 ZNF425 ZNF433 ZNF439 ZNF490 ZNF543 ZNF555 ZNF564 ZNF572 ZNF578 ZNF581 ZNF587 ZNF625 ZNF670 ZNF697 ZNF707 ZNF778 ZNF792 ZNF846 ZNHIT1 ZSCAN26
Entrez ID		6774	386675
HPRD ID		00026	11193
Ensembl ID		ENSG00000168610	ENSG00000272804
Uniprot IDs		P40763	P60409
PDB IDs		5AX3 5U5S 6QHD
Enriched GO Terms of Interacting Partners?
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