SOX10 and HOXA3

Number of citations of the paper that reports this interaction (PubMedID 16582099)
57

Data Source:
HPRD (two hybrid)

		SOX10	HOXA3
Description		SRY-box transcription factor 10	homeobox A3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Extrinsic Component Of Mitochondrial Outer Membrane	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding Promoter-specific Chromatin Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Peripheral Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Schwann Cell Proliferation Oligodendrocyte Development Positive Regulation Of Gliogenesis Central Nervous System Myelination Melanocyte Differentiation Positive Regulation Of Myelination Lacrimal Gland Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Morphogenesis Of A Branching Epithelium Cellular Response To Progesterone Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway	Angiogenesis Blood Vessel Remodeling Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Specification Of Animal Organ Position Gene Expression Glossopharyngeal Nerve Morphogenesis Thyroid Gland Development Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Animal Organ Formation Embryonic Skeletal System Morphogenesis Cartilage Development Parathyroid Gland Development Positive Regulation Of Receptor Binding
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Waardenburg syndrome (WS)
GWAS			Chronic venous disease ( 28374850) Diastolic blood pressure ( 27618448) Hypertension ( 27618448 30487518) Mean arterial pressure ( 27618448) Monocyte count ( 27863252) Pulse pressure ( 30487518) Systolic blood pressure ( 28135244 27618448 30487518)
Interacting Genes		29 interacting genes: ALX4 CDK6 CEBPA DLX5 EGR2 EXOC5 GSK3B HHEX HIVEP1 HOXA3 HOXC4 JUN MEOX1 NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 PRRX1 PRRX2 SP1 SUMO1 SUMO2 SUMO3 TCF12 UBE2I UTF1	9 interacting genes: ALX4 ARPC3 POT1 PWP1 SEC23B SOX10 TERF1 TINF2 ZDHHC17
Entrez ID		6663	3200
HPRD ID		03752	00842
Ensembl ID		ENSG00000100146	ENSG00000105997
Uniprot IDs		A0A024R1N6 P56693	A0A024RA33 A4D182 B3KPN8 O43365
PDB IDs
Enriched GO Terms of Interacting Partners?
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