SOX5 and TTC1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SOX5	TTC1
Description		SRY-box transcription factor 5	tetratricopeptide repeat domain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin	Peroxisomal Membrane Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	Protein Binding Unfolded Protein Binding
	Biological Process	Transcription By RNA Polymerase II Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Asymmetric Neuroblast Division Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation	Protein Folding
Pathways
Drugs
Diseases
GWAS		AIDS ( 19754311) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 29325848) Body mass index ( 25673413) Chronic back pain ( 30261039) Chronotype ( 30696823) Creatinine levels ( 29403010) Depression ( 29700475) Glomerular filtration rate ( 29403010) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 28552196) Inflammatory bowel disease ( 27569725) Juvenile osteochondritis dissecans ( 26422391) LDL peak particle diameter (total fat intake interaction) ( 26112879) Mortality in sepsis ( 27639821) Non-obstructive azoospermia ( 22197933) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Pelvic organ prolapse (moderate/severe) ( 26545240) PR interval ( 29127183 30046033 20062060) Response to antipsychotic treatment ( 20195266) Response to statin therapy ( 20339536) Resting heart rate ( 29769521 27798624) Schizophrenia ( 29483656) Systemic sclerosis ( 21779181) Systolic blood pressure ( 30224653) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149)	Diastolic blood pressure ( 27841878) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		26 interacting genes: APP ARID5A CBX8 CDC23 CDC25A CDK6 CRX FTH1 KAT5 KIFC3 LMO1 LMO2 MED27 MORN3 PRR20A RPS2 SMAD1 SMAD5 SMAD7 SOX6 SUMO1P1 TENT5B TLE5 TTC1 UQCRFS1 ZNF581	17 interacting genes: ACY1 CRY2 GNA15 GNAI2 GNAQ GNAS HRAS HSPA1A HSPA4 HSPA8 NDE1 PSTPIP1 SH3BP4 SOX5 SPP1 SREBF2 TGFBR1
Entrez ID		6660	7265
HPRD ID		18086	11881
Ensembl ID		ENSG00000134532	ENSG00000113312
Uniprot IDs		A0A024RB06 F5H0I3 P35711 T2CYZ2 T2CZM2	Q99614
PDB IDs
Enriched GO Terms of Interacting Partners?
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