SOX2 and NR5A1

Number of citations of the paper that reports this interaction (PubMedID 12732652)
38

Data Source:
HPRD (in vitro)

		SOX2	NR5A1
Description		SRY-box transcription factor 2	nuclear receptor subfamily 5 group A member 1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Nuclear Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Chromatin Organization Regulation Of Transcription, DNA-templated Cell Cycle Arrest Response To Wounding Anatomical Structure Morphogenesis Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Glial Cell Fate Commitment Pituitary Gland Development Adenohypophysis Development Positive Regulation Of Cell-cell Adhesion Cell Differentiation Forebrain Development Somatic Stem Cell Population Maintenance Tissue Regeneration Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Cell Fate Commitment Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Response To Growth Factor Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance	Luteinization Transcription Initiation From RNA Polymerase II Promoter Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Multicellular Organism Aging Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Deactivation of the beta-catenin transactivating complex Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by MECP2	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells
Drugs			(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia	Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Chronotype ( 30696823) Excessive hairiness ( 29895819) Eyebrow thickness ( 30248107) General risk tolerance (MTAG) ( 30643258) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Self-reported risk-taking behaviour ( 30181555)	Chronotype ( 30696823)
Interacting Genes		17 interacting genes: AKT1 ALX4 CASP8 CDX1 COP1 FZR1 L3MBTL3 MAPK3 NR5A1 OTUD7B POU2F1 POU5F1 SETD7 SUMO1 UBE2D3 UBR5 XPO1	31 interacting genes: AR CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 PIAS1 PITX1 PNRC2 PROX1 RAB14 RAD54L2 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TRAPPC2 TRERF1 UBE2I ZNF653
Entrez ID		6657	2516
HPRD ID		08921	01702
Ensembl ID		ENSG00000181449	ENSG00000136931
Uniprot IDs		A0A0U3FYV6 P48431	F1D8R8 Q13285
PDB IDs		1O4X 2LE4	1YOW 1ZDT 4QJR 4QK4
Enriched GO Terms of Interacting Partners?
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