NR5A1 and PNRC2

Number of citations of the paper that reports this interaction (PubMedID 11574675)
17

Data Source:
HPRD (two hybrid, in vivo)

		NR5A1	PNRC2
Description		nuclear receptor subfamily 5 group A member 1	proline rich nuclear receptor coactivator 2
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex	P-body Nucleus Nucleoplasm Golgi Apparatus Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding	Protein Binding
	Biological Process	Luteinization Transcription Initiation From RNA Polymerase II Promoter Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Multicellular Organism Aging Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases		Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Chronotype ( 30696823)	Obesity-related traits ( 23251661)
Interacting Genes		31 interacting genes: AR CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 PIAS1 PITX1 PNRC2 PROX1 RAB14 RAD54L2 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TRAPPC2 TRERF1 UBE2I ZNF653	21 interacting genes: APP AR DCP1A ESR1 ESR2 ESRRA ESRRG FBXO7 GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SPAG9 XRCC6 ZBTB16 ZBTB48
Entrez ID		2516	55629
HPRD ID		01702	17871
Ensembl ID		ENSG00000136931	ENSG00000189266
Uniprot IDs		F1D8R8 Q13285	Q9NPJ4
PDB IDs		1YOW 1ZDT 4QJR 4QK4	4B6H 5KQ1 5KQ4
Enriched GO Terms of Interacting Partners?
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