SOD3 and FBLN5

Number of citations of the paper that reports this interaction (PubMedID 15528465)
43

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SOD3	FBLN5
Description		superoxide dismutase 3	fibulin 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Golgi Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Heparin Binding	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity
	Biological Process	Response To Hypoxia Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Response To Copper Ion Oxidation-reduction Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Cell-matrix Adhesion Negative Regulation Of Angiogenesis Extracellular Matrix Organization Positive Regulation Of Osteoblast Proliferation Protein Localization To Cell Surface Positive Regulation Of Transcription By RNA Polymerase II Secretion Elastic Fiber Assembly Intramembranous Bone Growth Regulation Of Removal Of Superoxide Radicals
Pathways		Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Blood protein levels ( 30072576 29875488) Major depressive disorder ( 23377640)	Diastolic blood pressure ( 30578418) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		2 interacting genes: FBLN5 SGTA	21 interacting genes: ATN1 GFI1B GSC LGMN LOXL1 LPA MEOX2 NDUFA4 OTX1 PAXIP1 PDIA3 PPP2R5C PRNP PSMC1 SERPINA1 SERPINA5 SOD3 ST3GAL3 TOP3B TRIP13 XCL1
Entrez ID		6649	10516
HPRD ID		01708	05204
Ensembl ID		ENSG00000109610	ENSG00000140092
Uniprot IDs		A0A140VJU8 P08294	A0A024R6G3 Q9UBX5
PDB IDs		2JLP
Enriched GO Terms of Interacting Partners?
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