FBLN5 and ST3GAL3

		FBLN5	ST3GAL3
Description		fibulin 5	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity	N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Cell-matrix Adhesion Negative Regulation Of Angiogenesis Extracellular Matrix Organization Positive Regulation Of Osteoblast Proliferation Protein Localization To Cell Surface Positive Regulation Of Transcription By RNA Polymerase II Secretion Elastic Fiber Assembly Intramembranous Bone Growth Regulation Of Removal Of Superoxide Radicals	Protein Glycosylation O-glycan Processing Keratan Sulfate Biosynthetic Process Sialylation
Pathways		Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Termination of O-glycan biosynthesis
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Diastolic blood pressure ( 30578418) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)	Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Schizophrenia ( 28991256)
Interacting Genes		21 interacting genes: ATN1 GFI1B GSC LGMN LOXL1 LPA MEOX2 NDUFA4 OTX1 PAXIP1 PDIA3 PPP2R5C PRNP PSMC1 SERPINA1 SERPINA5 SOD3 ST3GAL3 TOP3B TRIP13 XCL1	6 interacting genes: ACTG1 FBLN5 RPL8 SCAMP2 TTR ZBTB5
Entrez ID		10516	6487
HPRD ID		05204	05930
Ensembl ID		ENSG00000140092	ENSG00000126091
Uniprot IDs		A0A024R6G3 Q9UBX5	A0A2R8Y732 Q11203
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?