SNRNP70 and SMAD5

Number of citations of the paper that reports this interaction (PubMedID 15231748)
85

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SNRNP70	SMAD5
Description		small nuclear ribonucleoprotein U1 subunit 70	SMAD family member 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck U2-type Prespliceosome	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Protein-containing Complex SMAD Protein Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding SnRNA Binding U1 SnRNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding DEAD/H-box RNA Helicase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of ATPase Activity Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Negative Regulation Of Chaperone-mediated Autophagy	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Embryonic Pattern Specification Erythrocyte Differentiation BMP Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		mRNA Splicing - Major Pathway	Signaling by BMP
Drugs
Diseases
GWAS		Systolic blood pressure ( 30224653)	Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Sleep duration (short sleep) ( 30846698)
Interacting Genes		41 interacting genes: APP ARSF CDKL3 CEP63 CHERP CRP CTDP1 DDX17 GEMIN2 HNRNPA2B1 HTATSF1 IL32 IL7R LRP1 MYC NUDT21 PRKD2 PRMT5 PRPF40A RASGRF1 RELA RNF11 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SRPK1 SRPK2 SRSF1 SRSF10 SRSF2 TOP1 WBP4 ZRANB2	44 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WWP1 ZEB2 ZNF8
Entrez ID		6625	4090
HPRD ID		01617	04381
Ensembl ID		ENSG00000104852	ENSG00000113658
Uniprot IDs		A0A024QZD5 P08621 Q9UFS1	Q68DB7 Q99717
PDB IDs		2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9	6FZS 6TCE
Enriched GO Terms of Interacting Partners?
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