SMN2 and TIAL1

Number of citations of the paper that reports this interaction (PubMedID 15304326)
68

Data Source:
HPRD (in vivo)

		SMN2	TIAL1
Description		survival of motor neuron 2, centromeric	TIA1 cytotoxic granule associated RNA binding protein like 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Perikaryon Gemini Of Coiled Bodies	Nucleus Nucleoplasm Cytoplasm Lysosome Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	DNA Binding RNA Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Nervous System Development Import Into Nucleus	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Defense Response Germ Cell Development Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Stem Cell Division
Pathways		snRNP Assembly	FGFR2 alternative splicing
Drugs		Nusinersen
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Depressive symptoms (stressful life events interaction) ( 27529621) Parkinson's disease ( 27182965) Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50) ( 27047539)
Interacting Genes		25 interacting genes: BLOC1S6 BYSL CHTOP DDX20 DHX9 FAM9B FBL GAR1 GEMIN2 HNRNPUL1 POLR1C POLR2A PPIG SMN1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG TIAL1 USP9X VPS28	3 interacting genes: MAPK1 SMN1 SMN2
Entrez ID		6607	7073
HPRD ID		09036	04563
Ensembl ID		ENSG00000205571	ENSG00000151923
Uniprot IDs		B4DP61 E7EQZ4 Q16637	Q01085 Q49AS9
PDB IDs		1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU	1X4G 2CQI 2DH7
Enriched GO Terms of Interacting Partners?
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