SMN2 and SNRPB

Number of citations of the paper that reports this interaction (PubMedID 9323129)
187

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		SMN2	SNRPB
Description		survival of motor neuron 2, centromeric	small nuclear ribonucleoprotein polypeptides B and B1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Perikaryon Gemini Of Coiled Bodies	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U7 SnRNP U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Telomerase Holoenzyme Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	RNA Binding Protein Binding Telomerase RNA Binding Histone Pre-mRNA DCP Binding U1 SnRNP Binding U2 SnRNP Binding
	Biological Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Nervous System Development Import Into Nucleus	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription Protein Methylation Brain Development Histone MRNA Metabolic Process RNA Splicing Import Into Nucleus
Pathways		snRNP Assembly	SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Drugs		Nusinersen
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes		25 interacting genes: BLOC1S6 BYSL CHTOP DDX20 DHX9 FAM9B FBL GAR1 GEMIN2 HNRNPUL1 POLR1C POLR2A PPIG SMN1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG TIAL1 USP9X VPS28	50 interacting genes: ASCC2 BANP CALCOCO2 CD2BP2 CDKN2A CEP55 CLNS1A COIL CTDP1 DAB1 DDX20 DHX9 ERG28 EXOSC8 FBN2 FNBP4 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GIGYF2 GOLGA2 IL7R KRT40 L3MBTL3 LSM11 LSM2 LSM8 PNMA1 PRMT5 PRMT7 PSMA3 RBPMS RFX6 SKIV2L SMN1 SMN2 SMNDC1 SNRPD1 SNRPD3 SNUPN SS18L1 STRAP STXBP2 STXBP3 TFIP11 TOP3B TRIM23 WBP4 WDR77
Entrez ID		6607	6628
HPRD ID		09036	01655
Ensembl ID		ENSG00000205571	ENSG00000125835
Uniprot IDs		B4DP61 E7EQZ4 Q16637	P14678 Q66K91
PDB IDs		1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU	1D3B 3CW1 3JCR 3PGW 4PJO 4WZJ 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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