SNAI2 and PIAS4

Number of citations of the paper that reports this interaction (PubMedID 30612578)
4

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SNAI2	PIAS4
Description		snail family transcriptional repressor 2	protein inhibitor of activated STAT 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Transferase Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Notch Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Vitamin D Biosynthetic Process Neural Crest Cell Development Positive Regulation Of Cell Migration Negative Regulation Of Chondrocyte Differentiation Regulation Of Chemokine Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Histone Acetylation Desmosome Disassembly Pigmentation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Fat Cell Differentiation Regulation Of Osteoblast Differentiation White Fat Cell Differentiation Roof Of Mouth Development Epithelium Development Cartilage Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Notch Signaling Involved In Heart Development Negative Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Ionizing Radiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Stem Cell Proliferation Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Sumoylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Sumoylation Vitamin D Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases		Piebaldism Waardenburg syndrome (WS)
GWAS		Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252)	Chronic lymphocytic leukemia ( 28165464)
Interacting Genes		8 interacting genes: APP PIAS1 PIAS2 PIAS3 PIAS4 SAT1 TRIM23 UBE2I	82 interacting genes: ACTN1 ALDOA AR AREL1 BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KNTC1 KPNB1 KRT18 LAMP2 LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRKCZ PRPF40A PTN RIF1 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNAI2 SNIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TOP2A TP53 TRIM27 TRIM32 UBE2I UBE2K VHL VIM ZHX1 ZNF512B ZW10
Entrez ID		6591	51588
HPRD ID		03689	06910
Ensembl ID		ENSG00000019549	ENSG00000105229
Uniprot IDs		O43623	B3KMR4 Q8N2W9
PDB IDs
Enriched GO Terms of Interacting Partners?
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