SLPI and GRN

Number of citations of the paper that reports this interaction (PubMedID 12526812)
215

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		SLPI	GRN
Description		secretory leukocyte peptidase inhibitor	granulin precursor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Cell Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Chaperone Binding
	Biological Process	Immune Response Negative Regulation Of Endopeptidase Activity Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Modification Of Morphology Or Physiology Of Other Organism Neutrophil Degranulation Negative Regulation Of Viral Genome Replication Innate Immune Response	Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Protein Stabilization Regulation Of Nervous System Development Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Aspartic-type Peptidase Activity Positive Regulation Of Lysosome Organization
Pathways		Neutrophil degranulation	Neutrophil degranulation
Drugs
Diseases			Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576 28240269)	Blood protein levels ( 30072576 29875488) Intracranial volume ( 22504418) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)
Interacting Genes		11 interacting genes: CTSB CTSL CTSS ELANE FAM9B GRN KLK3 MAPK8IP2 PLSCR1 PRSS2 SGTA	38 interacting genes: ARFGAP1 ATN1 ATXN7 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CRKL CRY1 DLK1 DLX2 ELANE FAM131C FANCL FRAT1 GFI1B GLRX3 HK3 HOXA1 HSPG2 KRT18 KRTAP10-7 KRTAP26-1 NLK OTX1 PIK3R2 POT1 PRKAB2 RAC1 SGTA SLPI SMAD9 SPRY2 TAT TGM2 TOP3B YY1
Entrez ID		6590	2896
HPRD ID		00121	00733
Ensembl ID		ENSG00000124107	ENSG00000030582
Uniprot IDs		P03973	P28799
PDB IDs		2Z7F 4DOQ	1G26 2JYE 2JYT 2JYU 2JYV
Enriched GO Terms of Interacting Partners?
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