ST3GAL3 and FBLN5

		ST3GAL3	FBLN5
Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 3	fibulin 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity
	Biological Process	Protein Glycosylation O-glycan Processing Keratan Sulfate Biosynthetic Process Sialylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Cell-matrix Adhesion Negative Regulation Of Angiogenesis Extracellular Matrix Organization Positive Regulation Of Osteoblast Proliferation Protein Localization To Cell Surface Positive Regulation Of Transcription By RNA Polymerase II Secretion Elastic Fiber Assembly Intramembranous Bone Growth Regulation Of Removal Of Superoxide Radicals
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Termination of O-glycan biosynthesis	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)	Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Schizophrenia ( 28991256)	Diastolic blood pressure ( 30578418) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		6 interacting genes: ACTG1 FBLN5 RPL8 SCAMP2 TTR ZBTB5	21 interacting genes: ATN1 GFI1B GSC LGMN LOXL1 LPA MEOX2 NDUFA4 OTX1 PAXIP1 PDIA3 PPP2R5C PRNP PSMC1 SERPINA1 SERPINA5 SOD3 ST3GAL3 TOP3B TRIP13 XCL1
Entrez ID		6487	10516
HPRD ID		05930	05204
Ensembl ID		ENSG00000126091	ENSG00000140092
Uniprot IDs		A0A2R8Y732 Q11203	A0A024R6G3 Q9UBX5
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?