PLEKHG2 and ACTN3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PLEKHG2	ACTN3
Description		pleckstrin homology and RhoGEF domain containing G2	actinin alpha 3 (gene/pseudogene)
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Ion Channel Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Muscle Filament Sliding Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		7 interacting genes: ACTN3 APP CDC42 GNG2 RAC1 RHOA XRN1	17 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A BRCA1 C1orf94 KCTD6 MYPN NEBL NRAP PLEKHG2 REL RNF111 SUMO1P1 TRAF1 TRAF2
Entrez ID		64857	89
HPRD ID		15148	02148
Ensembl ID		ENSG00000090924	ENSG00000248746
Uniprot IDs		Q9H7P9	A0A087WSZ2 B4DZQ2 Q08043
PDB IDs			1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?
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