SH3GL2 and MAST2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		SH3GL2	MAST2
Description		SH3 domain containing GRB2 like 2, endophilin A1	microtubule associated serine/threonine kinase 2
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GO Annotations	Cellular Component	Golgi Membrane Early Endosome Cytosol Plasma Membrane Cell Junction Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Basal Dendrite Photoreceptor Ribbon Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Presynaptic Cytosol	Cytoplasm Plasma Membrane Microtubule Cytoskeleton
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding Protein Kinase Binding Identical Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Phosphatase Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Synaptic Vesicle Uncoating Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Lipid Tube Assembly Membrane Organization Dendrite Extension Membrane Tubulation Membrane Bending Vesicle Scission Positive Regulation Of Membrane Tubulation Negative Regulation Of Maintenance Of Permeability Of Blood-brain Barrier Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Clathrin-dependent Endocytosis	Protein Phosphorylation Cytoskeleton Organization Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Interleukin-12 Biosynthetic Process Spermatid Differentiation
Pathways		Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Blood protein levels ( 28240269) Body mass index ( 25673413) Granulocyte count ( 27863252) Iron status biomarkers (total iron binding capacity) ( 28334935) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Red blood cell count ( 27863252) Reticulocyte count ( 27863252) Sum basophil neutrophil counts ( 27863252)
Interacting Genes		51 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	17 interacting genes: APP CDHR2 DYNLL1 PTEN RPS27A RPS6KA1 SH3GL2 SLC34A1 SLC9A3 SMN1 SNTB2 SRPK2 STK36 SUMO2 TK1 TRAF2 TRAF6
Entrez ID		6456	23139
HPRD ID		05125	11294
Ensembl ID		ENSG00000107295	ENSG00000086015
Uniprot IDs		Q7Z376 Q99962	Q6P0Q8
PDB IDs		1X03 1X04 2D4C 2DBM	2KQF 2KYL
Enriched GO Terms of Interacting Partners?
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